乌司他丁联合三七总皂甙对急性胰腺炎大鼠氧自由基的影响
急性胰腺炎;氧自由基;SOD;MDA;乌司他丁;三七总皂甙,王宏志,刘俊,宋慧,李磊,侯晓华,通讯作者:,Effectsofulinastatincombinedwithpanaxnotoginsengsaponinsonoxygenfreer
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王宏志, 刘俊, 宋慧, 李磊, 侯晓华, 华中科技大学同济医学院附属协和医院消化内科 湖北省武汉市 430022
通讯作者: 刘俊, 430022, 华中科技大学同济医学院附属协和医院消化内科. liujun_99@126.com
收稿日期: 2007-03-12 接受日期: 2007-04-13
Effects of ulinastatin combined with panax notoginseng saponins on oxygen free radicals in rats with acute pancreatitis
Hong-Zhi Wang, Jun Liu, Hui Song, Lei Li, Xiao-Hua Hou
Hong-Zhi Wang, Jun Liu, Hui Song, Lei Li, Xiao-Hua Hou, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Correspondence to: Jun Liu, Department of Gastroenterology, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430022, China. liujun_99@126.com
Received: 2007-03-12 Accepted: 2007-04-13
Abstract
AIM: To investigate the effects of ulinastatin combined with panax notoginseng saponins (PNS) on oxygen free radicals in rats with acute pancreatitis (AP).
METHODS: Seventy-five Sprague-Dawley rats were divided into five equal groups: group A (sham-operated), B (AP), C (treated with ulinastatin), D (treated with panax notoginseng saponins) and E (treated with ulinastatin combined with panax notoginseng saponins). A rat model of AP was created by retrogression injection of sodium taurocholate though pancreas biliferous ducts. Serum superoxide dismutase (SOD) and malondialdehyde (MDA) levels in each experimental group were observed at 3, 6 and 12 h.
RESULTS: The level of SOD in group B decreased while the MDA increased. Levels of SOD in groups C and D were higher than that in group B (274.750 ± 14.44 U/L and 281.420 ± 16.48 U/L vs 204.440 ± 14.87 U/L, P < 0.05) while the levels of MDA were lower (6.85 ± 0.65 µmol/L and 6.78 ± 0.56 µmol/L vs 9.25 ± 0.22 µmol/L, P < 0.05). The level of SOD in group E was higher than that in group C (318.360 ± 13.71 U/L vs 274 ......
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