L-精氨酸对胰腺炎相关性腹水诱导的肾细胞凋亡的疗效
L-精氨酸;胰腺炎;腹水;肾损伤;细胞凋亡;一氧化氮,程若川,刘其雨,苏艳军,张建明,刁畅,罗华友,程若川,通讯作者:,CurativeeffectsofL-arginineonapoptosisofrenalcellsinducedbypan
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程若川, 刘其雨, 苏艳军, 张建明, 刁畅, 罗华友, 昆明医学院第一附属医院普通外科 云南省昆明市 650032
程若川, 教授, 主要从事普通外科疾病的临床及基础研究.
通讯作者: 刘其雨, 650032, 云南省昆明市西昌路295号, 昆明医学院第一附属医院普通外科. liuqiyu_12@hotmail.com
电话: 0871-5324888-2432
收稿日期: 2007-01-26 接受日期: 2007-03-17
Curative effects of L-arginine on apoptosis of renal cells induced by pancreatitis associated ascitic fluid
Ruo-Chuan Cheng, Qi-Yu Liu, Yan-Jun Su, Jian-Ming Zhang, Chang Diao, Hua-You Luo
Ruo-Chuan Cheng, Qi-Yu Liu, Yan-Jun Su, Jian-Ming Zhang, Chang Diao, Hua-You Luo, Department of General Surgery, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
Correspondence to: Qi-yu Liu, Department of General Surgery, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China. liuqiyu_12@hotmail.com
Received: 2007-01-26 Accepted: 2007-03-17
Abstract
AIM: To explore the mechanism of acute renal injury in severe acute pancreatitis (SAP) and the effect of the conservative mechanism ofL-arginine.
METHODS: Sixty SAP model rats were established by retrograde injection of 5% sodium taurocholate into the pancreatic duct and then the PAAF collected for reservation. Another 60 rats were established as perforative peritonitis (PP) models, and their perforative peritonitis associated ascitic fluid (PPAF) was collected. Another ninety SD rats were randomly divided into five groups: NS, PAAF, PPAF, PAAF + L-arg and PPAF + L-arg. Serum concentrations of amylase (Amyl), urea nitrogen (BUN), creatinine and nitric oxide were determined at 12 hours post-operation. The renal cell apoptosis rate and inducible nitric oxide synthase activity were examined. Histological observation was performed.
RESULTS: The amylase, blood urea nitrogen, and creatinine levels of serum in the PAAF + L-arg and PPAF + L-arg groups were lower than those in the PAAF and PPAF groups (Amyl: 1925 ......
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