大鼠梗阻性胆管炎细胞免疫功能降低及中药锦红片的影响
中药锦红片;梗阻性胆管炎;胸腺;细胞免疫;凋亡;酶联免疫法;末端脱氧核苷酸转移酶缺口标记,章学林,张静喆,顾宏刚,马恩伟,朱培庭,通讯作者:,Mechanismsofdecreasedcellularimmunefunctionandthei
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章学林, 张静喆, 顾宏刚, 马恩伟, 朱培庭, 上海中医药大学附属龙华医院外科 上海市 200032
上海市重点学科课题资助项目, No. T0304
上海市卫生系统百人计划课题经费资助项目, No. 03HBR-29
通讯作者: 章学林, 200032, 上海中医药大学附属龙华医院外科. shanghaizxl@sina.com
电话: 021-64385700-3815
收稿日期: 2007-04-04 接受日期: 2007-04-21
Mechanisms of decreased cellular immune function and the impact of Jinhong Tablets during obstructive cholangitis
Xue-Lin Zhang, Jing-Zhe Zhang, Hong-Gang Gu, En-Wei Ma, Pei-Ting Zhu
Xue-Lin Zhang, Jing-Zhe Zhang, Hong-Gang Gu, En-Wei Ma, Pei-Ting Zhu,Department of Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Supported by:Scientific Research Project of Shanghai Municipal Key Academic Discipline, No. T0304; One Hundred Talents Scientific Research Project of Health System in Shanghai, No. 03HBR-29
Correspondence to:Xue-Lin Zhang, Department of Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. shanghaizxl@sina.com
Received:2007-04-04 Accepted:2007-04-21
Abstract
AIM: To explore the mechanism of decreased cellular immune function and the effect of Jinhong Tablets, a Chinese herbal medicine, during the course of obstructive cholangitis.
METHODS: An obstructive cholangitis model was induced in 24 male Sprague–Dawley rats that were randomly divided into model (n = 8), Jinhong Tablet-treated (n = 8) and simple obstructive cholangitis (n = 8) groups. Four days after modeling, all rats were sacrificed and the interleukin (IL)-2, CD3+, CD4+ and CD8+ levels in plasma were measured by enzyme liked immunosorbent assay (ELISA). The endotoxin content was detected by a reagent kit. The index of apoptosis was determined by Tdt-mediated fluorescein-dUTP nick end labeling (TUNEL), and ultrastructure changes of the thymus and apoptosis were observed by electron microscopy ......
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