罗格列酮对小鼠日本血吸虫病肝纤维化基质金属蛋白酶-2的影响
过氧化物酶体增殖物激活受体γ;肝纤维化;MMP-2;TIMP-2,谌辉,贺永文,张景辉,刘文琪,通讯作者:,Effectsofrosiglitazoneonmatrixmetalloproteinase-2inmicewiths
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谌辉, 贺永文, 华中科技大学同济医学院附属协和医院传染科 湖北省武汉市 430030
张景辉, 华中科技大学同济医学院附属协和医院外科实验室 湖北省武汉市 430030
刘文琪, 华中科技大学同济医学院寄生虫学教研室 湖北省武汉市 430022
湖北省自然科学基金, No. 2005ABA170
通讯作者: 谌辉, 430030, 湖北省武汉市, 华中科技大学同济医学院附属协和医院传染科. chenhui0515@yahoo.com.cn
电话: 027-85726132
收稿日期: 2007-03-23 接受日期: 2007-05-11
Effects of rosiglitazone on matrix metalloproteinase-2 in mice with schistosomiasis and liver fibrosis
Hui Chen, Jing-Hui Zhang, Wen-Qi Liu, Yong-Wen He
Hui Chen, Yong-Wen He,Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Jing-Hui Zhang,Department of Surgical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Wen-Qi Liu,Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Supported by:The Natural Science Foundation of Hubei Province, No. 2005ABA170
Correspondence to:Hui Chen, Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. chenhui0515@yahoo.com.cn
Received:2007-03-23 Accepted:2007-05-11
Abstract
AIM: To study the effects of rosiglitazone, a peroxisome proliferator-activator receptor (gamma) ligand, on serum levels of matrix metalloproteinase-2 (MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2), along with the hepatic expression of MMP-2 and TIMP-2 mRNA in mice with liver fibrosis caused by Schistosoma japonicum infection.
METHODS: Fifty mice were divided into five groups: one uninfected group (A), and four schistosomiasis groups (B-E): without any treatment (B), praziquantel treatment (C), rosiglitazone treatment (D), and rosiglitazone and praziquantel treatment (E) ......
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