代谢综合征小鼠肝脏过氧化物增殖体受体g共同作用因子-1的表达
代谢综合征;非酒精性脂肪肝;过氧化物增殖体受体g共同作用因子-1;免疫印迹,刘聪,吴波,李莉,陈威,李玲,韩萍,郑长青,刘聪,通讯作者:,Expressionofperoxisomeproliferator-activated
 |
| 第6页 |
 |
| 第1页 |
参见附件(945KB，6页)。
刘聪, 吴波, 李莉, 陈威, 李玲, 韩萍, 中国医科大学附属第二医院内分泌科 辽宁省沈阳市 110003
郑长青, 中国医科大学附属第二医院消化内科 辽宁省沈阳市 110003
刘聪, 1986年中国医科大学本科毕业, 1996年中国医科大学研究生毕业, 2004年中国医科大学博士毕业, 副教授, 主要从事糖尿病分子生物学及遗传学研究.
辽宁省教育厅B类项目, No. 202010795
通讯作者: 刘聪, 110003, 沈阳市三好街36号, 中国医科大学附属第二医院内分泌科. liucongjp@yahoo.com
电话: 024-83956478
收稿日期: 2006-11-18 接受日期: 2007-03-17
Expression of peroxisome proliferator-activated receptor-g-coactivator–1 in liver of metabolic syndrome mice
Cong Liu, Bo Wu, Li Li, Wei Chen, Ling Li, Ping Han, Chang-Qing Zheng
Cong Liu, Bo Wu, Li Li, Wei Chen, Ling Li, Ping Han,Department of Endocrinology, Second Affiliated Hospital of China Medical University, Shenyang 110003, Liaoning Province, China
Chang-Qing Zheng,Department of Gastroenterology, Second Affiliated Hospital of China Medical University, Shenyang 110003, Liaoning Province, China
Supported by:Education Bureau of Liaoning Province, No. 202010795
Correspondence to:Cong Liu, Department of Endocrinology, Second Affiliated Hospital of China Medical University, Shenyang 110003, Liaoning Province, China. liucongjp@yahoo.com
Received:2006-11-18 Accepted:2007-03-17
Abstract
AIM: To investigate the expression of peroxisome proliferator-activated receptor-g-coactivator–1 (PGC-1) in the liver of metabolic syndrome mice.
METHODS: Ten female C57BL/6J mice (control group) were fed a normal diet, Fifteen were fed a high fat and sugar diet (metabolic syndrome mice model), made up of 5 fed a high fat and sugar diet for 8 weeks (experimental group: A subgroup) and 10 fed the same diet for 16 weeks (experimental group: B subgroup). Abdominal fat mass, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), insulin (INS), liver function and liver weight were measured. The lipid content and the protein expression of PGC-1 in liver were detected by Western blot ......
您现在查看是摘要介绍页，详见PDF附件(945KB，6页)。