CDX2基因与肠型胃癌关系的研究进展
果蝇相关同源异型框转录因子2;异型增生;肠化生;胃癌,武洋,辛彦,通讯作者:,Expressionofcaudal-relatedhomeoboxtranscriptionfactorcaudal-relatedhomeoboxtranscriptionfa
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武洋, 辛彦, 中国医科大学附属一院肿瘤研究所第四研究室 辽宁省沈阳市 110001
通讯作者: 辛彦, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属一院肿瘤研究所第四研究室.
yxin@mail.cmu.edu.cn
电话: 024-83282351 传真: 024-83282375
收稿日期: 2007-04-19 接受日期: 2007-05-22
Expression of caudal-related homeobox transcription factor caudal-related homeobox transcription factor 2 in intestinal-type carcinoma
Yang Wu, Yan Xin
Yang Wu, Yan Xin,Lad. 4 Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang City 110001, Liaoning Province, China
Correspondence to:Yan Xin, Lad.4 Cancer Institute, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. yxin@mail.cmu.edu.cn
Received:2007-04-19 Accepted:2007-05-22
Abstract
Gastric carcinoma can be divided into two types by the Lauren classification: intestinal and diffuse-type carcinoma. Intestinal-type carcinoma is thought to develop from normal mucosa, intestinal metasplasia and dysplasia, ultimately leading to gastric cancer. Caudal-related homeobox transcription factor 2 (CDX2), an intestinal-specific transcription factor, is a member of the caudal- related homeobox gene family and plays an important role in the development and differentiation of intestinal epithelium, and in the maintenance of intestinal phenotype. In normal adults, CDX2 is expressed in mucosa from the duodenum to the distal colon. Recent studies have found that aberrant expression of CDX2 plays a crucial role in intestinal metaplasia formation and intestinal carcinoma.
Key Words: Caudal-related homeobox transcription factor 2; Dysplasia; Intestinal metaplasia; Gastric carcinoma
Wu Y, Xin Y. Expression of caudal-related homeobox transcription factor caudal-related homeobox transcrip-tion factor 2 in intestinal-type carcinoma. Shijie Huaren Xiaohua Zazhi 2007;15(18):2037-2041 ......
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