遗传性非息肉病性大肠癌组织E-cad, β-cat和MMP-7表达在侵袭转移中的作用
遗传性非息肉病性大肠癌;散发性大肠癌;上皮钙黏附蛋白;β-连接素;基质金属蛋白酶-7;病理;免疫组化,遗传性非息肉病性大肠癌组织E-cad,β-cat和MMP-7表达在侵袭转移中的作用,顾国利,魏学明,王石林,周晓武,任力,李德昌,胡益云,顾国利,通讯作者:,ExpressionofE-
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顾国利, 魏学明, 王石林, 周晓武, 中国人民解放军空军总医院普通外科 北京市 100036
任力, 李德昌, 胡益云, 中国人民解放军空军总医院病理科 北京市 100036
顾国利, 2004年中国医科大学外科学普通外科专业硕士生, 主治医师, 讲师, 主要从事大肠癌临床肿瘤学的研究.
通讯作者: 王石林, 100036, 北京市, 中国人民解放军空军总医院普通外科. wangshilin@medmail.com.cn
电话: 010-66928302
收稿日期: 2007-04-13 接受日期: 2007-05-13
Expression of E-cadherin, β-catenin, matrix metalloproteinase-7 and its correlation to invasion/metastasis of hereditary non-polyposis colorectal cancer
Guo-Li Gu, Xue-Ming Wei, Shi-Lin Wang, Li Ren, Xiao-Wu Zhou, De-Chang Li, Yi-Yun Hu
Guo-Li Gu, Xue-Ming Wei, Shi-Lin Wang, Xiao-Wu Zhou,Department of General Surgery, Airforce General Hospital of Chinese PLA, Beijing 100036, China
Li Ren, De-Chang Li, Yi-Yun Hu,Department of Pathology, Airforce General Hospital of Chinese PLA, Beijing 100036, China
Correspondence to:Shi-Lin Wang, Department of General Surgery, Airforce General Hospital of Chinese PLA, Beijing 100036, China. wangshilin@medmail.com.cn
Received:2007-04-13 Accepted:2007-05-13
Abstract
AIM: To detect expression of E-cadherin (E-cad), β-catenin (β-cat) and matrix metalloproteinase-7 (MMP-7) in hereditary non-polyposis colorectal cancer (HNPCC) and sporadic colorectal cancer (CRC), and to analyze its relationship to the biological behavior of HNPCC.
METHODS: Protein expression of E-cad, β-cat and MMP-7 in 30 specimens of HNPCC, 30 of sporadic CRC and eight of normal colorectal tissues was detected by SP immunohistochemistry. Their corresponding clinical data were analyzed retrospectively.
RESULTS: The positive expression rates of E-cad and membrane β-cat in HNPCC patients were higher than those in sporadic CRC (E-cad, 86.7% vs 60.0%; membrane β-cat, 83.3% vs 50.0%, all P < 0.05). The positive expression rates of cytoplasm β-cat and MMP-7 in HNPCC patients were lower than those in sporadic CRC patients (cytoplasm β-cat, 46 ......
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