大肠癌和胃癌个体化疗的现状与未来
大肠癌;胃癌;个体化疗,刘宝瑞,钱晓萍,刘宝瑞,通讯作者:,Stateoftailoredchemotherapyforcolorectalandgastriccancers,Bao-RuiLiu,Xiao-PingQian,Corresponden
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刘宝瑞, 钱晓萍, 南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所 江苏省南京市 210008
刘宝瑞, 南京大学医学院附属鼓楼医院肿瘤中心主任, 南京大学临床肿瘤研究所所长, 教授, 博士生导师, 主要从事消化系肿瘤个体化疗的研究.
通讯作者: 刘宝瑞, 210008, 江苏省南京市, 南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所.
baoruiliu@nju.edu.cn
电话: 025-83304616-21002 传真: 025-83107081
收稿日期: 2007-04-11 接受日期: 2007-05-16
State of tailored chemotherapy for colorectal and gastric cancers
Bao-Rui Liu, Xiao-Ping Qian
Bao-Rui Liu, Xiao-Ping Qian,Oncology Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School; Clinical Oncology Institute of Nanjing University, Nanjing 210008, Jiangsu Province, China
Correspondence to:Bao-Rui Liu, Oncology Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School; Clinical Oncology Institute of Nanjing University, Nanjing 210008, Jiangsu Province, China. baoruiliu@nju.edu.cn
Received:2007-04-11 Accepted:2007-05-16
Abstract
Colorectal and gastric cancers are very common disease entities in China. Postoperative chemoradiotherapy has become the standard of care for treatment of colorectal and gastric cancers, mainly because most diagnoses are at late or advanced stages. Based on statistics from large sample studies and because of the heterogeneity among patients having the same site of cancer, there are variations in the effects and toxicity among those receiving standard chemotherapy. Tailored chemotherapy based on pharmacogenetics and pharmacogenomics has received much attention and has shown predictive potential. The present paper focuses on advances in tailored chemotherapy in colorectal and gastric cancers to determine the potential value of the drug-associated genes.
Key Words: Colorectal cancer; Gastric cancer; Individual chemotherapy
Liu BR, Qian XP. State of tailored chemotherapy for colorectal and gastric cancers. Shijie Huaren Xiaohua Zazhi 2007;15(18):1979-1982
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