胃癌组织VEGF-C和CXCR4的表达与淋巴结转移的关系
胃癌;淋巴结转移;血管内皮细胞生长因子C;CXC趋化因子受体4,安丽文,关一夫,刘永军,赵丹懿,徐惠绵,安丽文,通讯作者:,CorrelationofVEGF-CandCXCR4expressioncorrelateswith
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安丽文, 关一夫, 中国医科大学基础医学院生物化学与分子生物学教研室 辽宁省沈阳市 110001
刘永军, 中国医科大学第四附属医院神经外科 中国医科大学第一附属医院肿瘤外科研究生 辽宁省沈阳市 110032
赵丹懿, 徐惠绵, 中国医科大学第一附属医院肿瘤外科 辽宁省沈阳市 110001
安丽文, 中国医科大学基础医学院生物化学与分子生物学专业硕士研究生, 助教, 主要从事胃癌转移相关基因与基因芯片方面的研究.
国家自然科学基金资助项目, No. 30470451
通讯作者: 关一夫, 110001, 辽宁省沈阳市, 中国医科大学基础医学院生物化学与分子生物学教研室. yfguan@mail.cmu.edu.cn
电话: 024-23255240 传真: 024-23255240
收稿日期: 2007-03-30 接受日期: 2007-04-28
Correlation of VEGF-C and CXCR4 expression correlates with lymph node metastasis in gastric cancer
Li-Wen An, Yong-Jun Liu, Dan-Yi Zhao, Hui-Mian Xu, Yi-Fu Guan
Li-Wen An, Yi-Fu Guan,Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, Liaoning Province, China
Yong-Jun Liu,Department of Neurological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
Dan-Yi Zhao, Hui-Mian Xu,Department of Oncology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Supported by: the National Natural Science Foundation of China, No. 30470451
Correspondence to:Yi-Fu Guan, Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, Liaoning Province, China. yfguan@mail.cmu.edu.cn
Received:2007-03-30 Accepted:2007-04-28
Abstract
AIM: To investigate the expression and correlation of VEGF-C and CXCR4 in gastric cancer tissue.
METHODS: Semi-quantitative reverse transcriptase-polymerase chain reaction was performed to detect the expression of VEGF-C and CXCR4 according to cancer stage in cancer and adjacent tissues in 50 cases of gastric cancer.
RESULTS: The expression index of VEGF-C in gastric cancer stage pN1 (0.34 ± 0.08) was significantly higher than that in gastric cancer stage pN0 without regional lymph node metastasis (0 ......
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