老年消化道癌症患者抑郁与免疫抑制酸性蛋白的关系
抑郁;免疫抑制酸性蛋白;免疫;单向免疫琼脂扩散法;流式细胞仪;癌症;老年人,李荣,许青,郭静,钱建新,顾小强,武清,原凌燕,王杰军,通讯作者:,Relationshipbetweendepressionandserumimmunosuppressi
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李荣, 许青, 郭静, 钱建新, 顾小强, 武清, 原凌燕, 王杰军, 中国人民解放军第二军医大学长征医院肿瘤科 上海市 200070
通讯作者: 王杰军, 200070, 上海市, 中国人民解放军第二军医大学长征医院肿瘤科. jiejunw@csco.org.cn
电话: 021-66540109-7045
收稿日期: 2007-03-01 接受日期: 2007-03-31
Relationship between depression and serum immunosuppressive acid protein in patients with advanced digestive tract cancers
Rong Li, Qing Xu, Jing Guo, Jian-Xin Qian, Xiao-Qiang Gu, Qing Wu, Ling-Yan Yuan, Jie-Jun Wang
Rong Li, Qing Xu, Jing Guo, Jian-Xin Qian, Xiao-Qiang Gu, Qing Wu, Ling-Yan Yuan, Jie-Jun Wang,Department of Medical Oncology, Changzheng Hospital of the Second Military Medical University, Shanghai, 200070, China
Correspondence to:Jie-Jun Wang, Department of Medical Oncology, Changzheng Hospital of the Second Military Medical University, Shanghai, 200070, China. jiejunw@csco.org.cn
Received:2007-03-01 Accepted:2007-03-31
Abstract
AIM: To explore the relationships among depression, the degree of immunosupressive acidic protein (IAP), and the percentage of CD3, CD4, CD8, and NK in elderly patients with advanced digestive tract cancers; and to determine the effects of antidepressant therapy.
METHODS: Forty-three elderly patients with advanced digestive tract cancers were randomly enrolled in the study and divided into two groups. The degree of depression was evaluated by the Zung self-rating depression scale (SDS). IAP was examined by simple agar diffusion. Immunological parameters such as the percentage of T-lymphocyte subsets and natural killer (NK) cells in peripheral blood were determined and compared between the two groups of patients by flow cytometry. Patients who were depressed according to the scores of the SDS took antidepressant therapy. After patients were assessed as normal, the immunological parameters were again determined.
RESULTS: The depression rate was 44%. SDS was positively correlated with the level of IAP (r = 0 ......
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