CYP2C19基因多态性与质子泵抑制剂对消化性溃疡患者抑酸效应的关系
奥美拉唑;雷贝拉唑;埃索美拉唑;抑酸效应;CYP2C19基因多态性;夜间酸突破,牛春燕,罗金燕,王学勤,木尼拉,通讯作者:,Relationshipbetweentheacid-suppressionefficacyofpr
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牛春燕, 西安医学院附属医院消化内科 陕西省西安市 710077
罗金燕, 王学勤, 西安交通大学第二医院消化内科 陕西省西安市 710077
木尼拉, 新疆医科大学第一附属医院干部病房综合内科 新疆维吾尔自治区 乌鲁木齐市 830054
通讯作者: 牛春燕, 710077, 陕西省西安市沣镐西路48号, 西安医学院附属医院消化内科. nchy69@163.com
电话: 029-84278402
收稿日期: 2007-02-03 接受日期: 2007-03-06
Relationship between the acid-suppression efficacy of proton pump inhibitors and the CYP2C19 genetic polymorphism in patients with peptic ulcer
Chun-Yan Niu, Jin-Yan Luo, Ni-La Mu, Xue-Qin Wang
Chun-Yan Niu, Department of Gastroenterology, the Affiliated Hospital of Xi’an Medical College, Xi’an 710077, Shaanxi Province, China
Jin-Yan luo, Xue-Qin Wang, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710077, Shaanxi Province, China
Ni-La Mu, Cadre's Ward, Department of Comprehensive Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang Uygur Autonomous Region, China
Correspondence to: Chun-Yan Niu, Department of Gastroenterology, the Affiliated Hospital of Xi’an Medical College, 48 Fenghao West Road, Xi’an 710077, Shaanxi Province, China. nchy69@163.com
Received: 2007-02-03 Accepted: 2007-03-06
Abstract
AIM: To investigate the acid-suppression efficacy of proton pump inhibitors (PPIs) in relation to the CYP2C19 genetic polymorphism in patients with peptic ulcer.
METHODS: In an open, randomized controlled trial, 59 patients with active peptic ulcer were randomly assigned to receive one of three PPIs in a single dose (20 mg of each drug): omeprazole (OME) (n = 19), rabeprazole (RAB) (n = 20) and esomeprazole (ESO) (n = 20). The level of 24 hours intragastric pH was dynamically monitored. The 24 hours and night acid-suppression effects of the three drugs were observed. The CYP2C19 genotype was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in all patients ......
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