HBV宫内传播的研究进展
乙型肝炎病毒;宫内感染,陈天艳,刘敏,陈云茹,张树林,通讯作者:,AdvancesinresearchonintrauterineHBVinfection,Tian-YanChen,MinLiu,Yun-RuChen,Shu-LinZhang,Correspondenc
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陈天艳, 刘敏, 陈云茹, 张树林, 西安交通大学医学院第一附属医院传染科 陕西省西安市 710061
通讯作者: 陈天艳, 710061, 陕西省西安市, 西安交通大学医学院第一附属医院传染科. chentianyan@126.com
电话: 029-85323262 传真: 029-85252812
收稿日期: 2007-05-15 接受日期: 2007-06-27
Advances in research on intrauterine HBV infection
Tian-Yan Chen, Min Liu, Yun-Ru Chen, Shu-Lin Zhang
Tian-Yan Chen, Min Liu, Yun-Ru Chen, Shu-Lin Zhang, Department of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Correspondence to: Tian-Yan Chen, Department of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. chentianyan@126.com
Received: 2007-05-15 Accepted: 2007-06-27
Abstract
The main cause of failure of immunization for hepatitis B virus (HBV) is intrauterine infection. Possible routes of infection include trans-placental transmission, and transmission of peripheral blood mononuclear cells and germ cells. Some factors, such as the level of HBV DNA in maternal serum, HBV genotype, and hereditary factors, can affect intrauterine HBV infection. Many clinical studies have indicated that using hepatitis B immunoglobulin or lamivudine in the third trimester of pregnancy can interrupt intrauterine transmission of HBV. However, this therapy needs to be confirmed by a randomized controlled clinical trial in a large patient population. Therefore, examining the mechanisms of intrauterine infection of HBV and determining feasible therapy are crucial to controlling the HBV epidemic in China.
Key Words: Hepatitis B virus; Intrauterine infection
Chen TY, Liu M, Chen YR, Zhang SL. Advances in research on intrauterine HBV infection. Shijie Huaren Xiaohua Zazhi 2007;15(19):2138-2143
摘要
HBV宫内感染是乙肝免疫失败的主要原因, HBV宫内传播的途径主要有胎盘途径、PBMCS途径及经生殖细胞的传播. 其中胎盘的渗漏或胎盘细胞的感染是主要的途径 ......
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