miRNA与食管癌
MicroRNA;肿瘤;癌基因,抑癌基因;食管癌,贺小停,曹秀峰,通讯作者:,RelationshipbetweenmicroRNAandesophagealcarcinoma,Xiao-TingHe,Xiu-FengCao,Correspondenceto:,Receive
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贺小停, 曹秀峰, 南京医科大学附属南京第一医院肿瘤中心 江苏省南京市 210029
通讯作者: 曹秀峰, 210029, 江苏省南京市, 南京医科大学附属南京第一医院肿瘤中心科. cxf551101@sina.com
电话: 0255-2271474
收稿日期: 2007-04-28 接受日期: 2007-05-22
Relationship between microRNA and esophageal carcinoma
Xiao-Ting He, Xiu-Feng Cao
Xiao-Ting He, Xiu-Feng Cao, Oncology Center, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondence to: Xiu-Feng Cao, Oncology Center, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. cxf551101@sina.com
Received: 2007-04-28 Accepted: 2007-05-22
Abstract
A class of small non-coding RNAs, 21–25 nucleotides long, is widely distributed in all plants and animals. These are known as microRNA (miRNA), and are highly conserved in evolution, expressing in special tissues and timing. They function as negative regulators of genetic pathways and regulate crucial biological processes in cells through proliferation, differentiation and apoptosis. Therefore, alterations of miRNA may result in some critical anthological processes. Previous studies have shown that miRNA can function as oncogenes/tumor suppressor genes. Therefore, expression profiling of human tumors is associated with diagnosis, differentiation stage and prognosis, and can be used to classify human cancers better than mRNA can. This review focused on miRNA and discussed its generation, functional mechanisms, its relationship with tumors, and research methods, as well as its potential role in the diagnosis, staging and biological therapy for esophageal carcinoma.
Key Words: MicroRNA; Tumor; Oncogenes/Tumor suppressors genes; Esophageal carcinoma
He XT, Cao XF. Relationship between microRNA and esophageal carcinoma. Shijie Huaren Xiaohua Zazhi 2007;15(19):2133-2137
摘要
动植物中广泛存在着一大类小的非编码蛋白质的RNA, 21-25个核苷酸长度, 被命名为microRNA(miRNA) ......
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