肝炎病毒感染与胰岛素抵抗
乙肝病毒;丙肝病毒;慢性感染;胰岛素抵抗,范小玲,张维燕,通讯作者:,Hepatitisvirusinfectionandinsulinresistance,Xiao-LingFan,Wen-YanZhang,Correspondenceto:,Received:
 |
| 第1页 |
参见附件(513KB，5页)。
范小玲, 张维燕, 北京地坛医院 北京市 100011
范小玲, 主任医师, 北京大学医学部教授, 主要从事病毒性肝炎合并糖尿病的临床研究工作.
通讯作者: 范小玲, 100011, 北京市北京地坛医院. fanxl2001@yahoo.com
电话: 010-64211031-2457
收稿日期: 2007-06-11 接受日期: 2007-07-01
Hepatitis virus infection and insulin resistance
Xiao-Ling Fan, Wen-Yan Zhang
Xiao-Ling Fan, Wen-Yan Zhang, Beijing Ditan Hospital, Beijing 100011, China
Correspondence to: Xiao-ling Fan, Beijing Ditan Hospital, Beijing 100011, China. fanxl2001@yahoo.com
Received: 2007-06-11 Accepted: 2007-07-01
Abstract
Extrahepatic tissues, as well as liver damage, is involved in hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Recent studies suggest that chronic HBV and HCV infections are correlated with metabolic diseases such as diabetes mellitus and fatty liver. Insulin resistance plays a critical role in hepatitis-virus-related metabolic diseases, and may facilitate the progression of hepatic fibrosis and influence the efficacy of antiviral therapy. Diabetes mellitus may increase the risk of developing hepatocellular carcinoma. Thus, careful attention needs to be paid to insulin resistance and metabolic diseases associated with chronic HBV and HCV infections.
Key Words: Hepatitis B virus; Hepatitis C virus; Chronic Infection; Insulin resistance
Fan XL, Zhang WY. Hepatitis virus infection and insulin resistance. Shijie Huaren Xiaohua Zazhi 2007;15(19):2077-2081
摘要
肝炎病毒慢性持续感染主要是由乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)所致, 除了引起肝脏损害外, 还与一些肝外组织的损害密切相关. 近年来, 研究资料显示慢性HCV和HBV感染与糖尿病和脂肪肝等代谢性疾病的发病密切相关, 而胰岛素抵抗(IR)可能是其发病机制的中心环节. IR也是肝纤维化进展的相关因素, 并影响慢性肝炎病毒感染时抗病毒治疗的疗效. 此外, 糖尿病还可能增加肝炎病毒致癌的作用, 应该引起肝病医师的高度重视. 本文就近年来对HCV和HBV感染中IR发生机制方面的研究, IR在HCV和HBV感染相关的糖尿病和脂肪肝中的作用和影响及其对临床的指导意义作一述评.
关键词: 乙肝病毒; 丙肝病毒; 慢性感染; 胰岛素抵抗
范小玲, 张维燕. 肝炎病毒感染与胰岛素抵抗. 世界华人消化杂志 2007;15(19):2077-2081
0 引言
肝炎病毒慢性持续感染主要是由乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)所致, 除引起肝脏损害外, 还与一些肝外组织的损害密切相关 ......
您现在查看是摘要介绍页，详见PDF附件(513KB，5页)。