直肠癌中MIC-1, VEGF和P53表达的临床意义
直肠癌;巨噬细胞抑制因子-1;血管内皮生长因子;P53;免疫组化,直肠癌中MIC-1,VEGF和P53表达的临床意义,王志宇,高健,韩强,毕雪冰,程魏,朱熹珍,杨渤彦,通讯作者:,Expressionofmacrophageinhibitorycytokine-1,vascularendothe
 |
| 第1页 |
参见附件(549KB，4页)。
王志宇, 高健, 韩强, 毕雪冰, 程魏, 朱熹珍, 保定市第三医院肿瘤内科 河北省保定市 071000
杨渤彦, 北京中国医学科学院肿瘤医院内科 北京市 100021
王志宇, 保定市第三医院肿瘤内科硕士, 主治医师, 主要从事恶性肿瘤基础和临床研究.
通讯作者: 杨渤彦, 100021, 北京中国医学科学院肿瘤医院内科. yby6599.yong@vip.sina.com
电话: 0312-5070399
收稿日期: 2007-04-26 接受日期: 2007-05-16
Expression of macrophage inhibitory cytokine-1, vascular endothelial growth factor and P53 and its clinical significance in rectal cancer
Zhi-Yu Wang, Bo-Yan Yang, Jian Gao, Qiang Han, Xue-Bing Bi, Wei Cheng, Xi-Zhen Zhu
Zhi-Yu Wang, Jian Gao, Qiang Han, Xue-Bing Bi, Wei Cheng, Xi-Zhen Zhu, Department of Oncology, the Third Hospital of Baoding, Baoding 071000, Hebei Province, China
Bo-Yan Yang, Department of Oncology, Chinese Academy of Medical Sciences, Beijing 100021, China
Correspondence to: Dr. Bo-Yan Yang, Department of Oncology, Chinese Academy of Medical Sciences, Beijing 100021, China. yby6599.yong@vip.sina.com
Received: 2007-04-26 Accepted: 2007-05-16
Abstract
AIM: To investigate the expression of macrophage inhibitory cytokine-1 (MIC-1), vascular endothelial growth factor (VEGF) and P53 in rectal cancer, and its relationship to clinicopathological parameters.
METHODS: Expression of MIC-1, VEGF and P53 in 73 cases of rectal cancer was assessed by immunohistochemistry, and its correlation with clinicopathological factors was statistically analyzed.
RESULTS: Expression of MIC-1, VEGF and P53 had a significant correlation with clinical stage (χ2MIC-1 = 37.534, χ2VEGF = 54.451, χ2P53 = 16.834, respectively; P < 0.01). There was a significant linear relationship between the levels of the three oncoproteins and clinical stage in patients with rectal cancer (r = 0.918, P = 0.000). The expression of MIC-1 also had a positive correlation with the expression of VEGF and P53 (r = 0.808, r = 0 ......
您现在查看是摘要介绍页，详见PDF附件(549KB，4页)。