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编号:11495401
利多卡因对造影剂及胰管结扎所致兔胰腺炎动物模型的影响
http://www.100md.com 2007年7月18日 许良璧, 黄永辉, 李俐佳, 车筑萍
利多卡因;急性胰腺炎;胰管远端括约肌压力;兔,许良璧,车筑萍,李俐佳,黄永辉,许良璧,通讯作者:,Effectsoflidocaineinanexperimentalmodelofacutepancreatitisinducedb
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     许良璧, 车筑萍, 贵阳医学院附属医院内镜中心 贵州省贵阳市 550001

    李俐佳,
贵阳市第一人民医院检验科 贵州省贵阳市 550001

    黄永辉,
北京大学第三医院消化内科 北京市 100001

    许良璧,
2005年贵阳医学院硕士, 主治医师, 主要从事消化内镜的诊断及治疗.

    通讯作者:
许良璧, 550001, 贵州省贵阳市, 贵阳医学院附属医院内镜中心. gzxlb@sina.com

    电话: 0851-6855119-3173

    收稿日期: 2007-02-26 接受日期: 2007-05-22

    Effects of lidocaine in an experimental model of acute pancreatitis induced by contrast medium and pancreatic duct ligation

    
Liang-Bi Xu, Yong-Hui Huang, Li-Jia Li, Zhu-Ping Che

    Liang-Bi Xu, Zhu-Ping Che,
Digestive Endoscopy Center, The Affiliated Hospital of Guiyang Medical College, Guiyang 550001, Guizhou Province, China

    Li-Jia Li,
Clinical Laboratory, The First People’s Hospital of Guiyang City, Guiyang 550001, Guizhou Province, China

    Yong-Hui Huang,
Department of Gastroenterology, The Third Hospital of Peking University, Beijing 100001, China

    Correspondence to:
Liang-Bi Xu, Digestive Endoscopy Center, the Affiliated Hospital of Guiyang Medical College, Guiyang 550001, Guizhou Province, China. gzxlb@sina.com

    Received:
2007-02-26 Accepted:2007-05-22

    Abstract

    AIM: To explore the effects of lidocaine in an experimental model of acute pancreatitis induced by contrast medium and pancreatic duct ligation, as well the rabbits’ pancreatic sphincter pressure.

    METHODS: Twenty-four rabbits were randomly divided into four groups, each containing six animals. The rabbit model of acute pancreatitis was set up by retrograde injection of 300 g/L Urografin in biliopancreatic duct and pancreatic duct obstruction. Before operation, lidocaine or distilled water was locally sprayed on the pancreatic duct distal sphincter in theⅠor Ⅱ group, respectively. Then the pancreatic sphincter pressure was determined and pancreas pathological changes were observed after 24 hours. The group Ⅲ rabbits only underwent manometry of pancreatic duct sphincter, and group Ⅳ underwent sham operation ......

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