利多卡因对造影剂及胰管结扎所致兔胰腺炎动物模型的影响
利多卡因;急性胰腺炎;胰管远端括约肌压力;兔,许良璧,车筑萍,李俐佳,黄永辉,许良璧,通讯作者:,Effectsoflidocaineinanexperimentalmodelofacutepancreatitisinducedb
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许良璧, 车筑萍, 贵阳医学院附属医院内镜中心 贵州省贵阳市 550001
李俐佳, 贵阳市第一人民医院检验科 贵州省贵阳市 550001
黄永辉, 北京大学第三医院消化内科 北京市 100001
许良璧, 2005年贵阳医学院硕士, 主治医师, 主要从事消化内镜的诊断及治疗.
通讯作者: 许良璧, 550001, 贵州省贵阳市, 贵阳医学院附属医院内镜中心. gzxlb@sina.com
电话: 0851-6855119-3173
收稿日期: 2007-02-26 接受日期: 2007-05-22
Effects of lidocaine in an experimental model of acute pancreatitis induced by contrast medium and pancreatic duct ligation
Liang-Bi Xu, Yong-Hui Huang, Li-Jia Li, Zhu-Ping Che
Liang-Bi Xu, Zhu-Ping Che,Digestive Endoscopy Center, The Affiliated Hospital of Guiyang Medical College, Guiyang 550001, Guizhou Province, China
Li-Jia Li,Clinical Laboratory, The First People’s Hospital of Guiyang City, Guiyang 550001, Guizhou Province, China
Yong-Hui Huang,Department of Gastroenterology, The Third Hospital of Peking University, Beijing 100001, China
Correspondence to:Liang-Bi Xu, Digestive Endoscopy Center, the Affiliated Hospital of Guiyang Medical College, Guiyang 550001, Guizhou Province, China. gzxlb@sina.com
Received:2007-02-26 Accepted:2007-05-22
Abstract
AIM: To explore the effects of lidocaine in an experimental model of acute pancreatitis induced by contrast medium and pancreatic duct ligation, as well the rabbits’ pancreatic sphincter pressure.
METHODS: Twenty-four rabbits were randomly divided into four groups, each containing six animals. The rabbit model of acute pancreatitis was set up by retrograde injection of 300 g/L Urografin in biliopancreatic duct and pancreatic duct obstruction. Before operation, lidocaine or distilled water was locally sprayed on the pancreatic duct distal sphincter in theⅠor Ⅱ group, respectively. Then the pancreatic sphincter pressure was determined and pancreas pathological changes were observed after 24 hours. The group Ⅲ rabbits only underwent manometry of pancreatic duct sphincter, and group Ⅳ underwent sham operation ......
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