射频消融对鼠肝肿瘤血管内皮生长因子及其受体Flk-1表达的影响
射频;肝肿瘤;大鼠;血管内皮生长因子;血管内皮生长因子受体Flk-1,孔文韬,陈骏,仇毓东,张炜炜,通讯作者:,Influenceofradiofrequencyablationonvascularendothelialgrowth
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孔文韬, 陈骏, 仇毓东, 张炜炜, 南京大学医学院附属鼓楼医院肝胆外科 江苏省南京市 210008
通讯作者: 仇毓东, 210008, 江苏省南京市中山路321号, 南京大学医学院附属鼓楼医院肝胆外科. yudongqiu510@hotmail.com
电话: 025-83304616-11602
收稿日期: 2007-04-14 接受日期: 2007-04-28
Influence of radiofrequency ablation on vascular endothelial growth factor and fetal liver kinase 1 in transplanted liver cancer in rats
Wen-Tao Kong, Jun Chen, Yu-Dong Qiu, Wei-Wei Zhang
Wen-Tao Kong, Jun Chen, Yu-Dong Qiu, Wei-Wei Zhang,Department of Hepatobiliary Surgery, Drumtower Hospital, the Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
Correspondence to:Yu-Dong Qiu, Department of Hepatobiliary Surgery, Drumtower Hospital, the Medical College of Nanjing University, 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. yudongqiu510@hotmail.com
Received:2007-04-14 Accepted:2007-04-28
Abstract
AIM: To study the influence of radiofrequency ablation (RFA) on vascular endothelial growth factor (VEGF) and fetal liver kinase 1 (Flk-1) in a rat transplanted liver cancer model.
METHODS: A rat liver cancer model was established by injecting Walker carcinosarcoma 256 tumor cells into the livers of the rats. After tumor growth had proceeded for about 9 or 10 days, we surgically treated the rats with RFA. Rats were randomly divided into control and RFA groups. After treatment, rats were randomly divided into two groups, and were killed after 1 or 3 days to obtain liver specimens. Expression of VEGF and Flk-1 was observed in the tumor and adjacent tissues by an immunohistochemical Elivision method at 1 and 3 days after RFA.
RESULTS: The expression of VEGF in adjacent tissues was higher (P = 0.014, and P = 0.013) and the expression of VEGF in remnant tumors was lower at 1 and 3 days after RFA than that before RFA (P = 0.015, P = 0.013). The expression of Flk-1 1 day after RFA in the adjacent tissues was higher than that in controls (P = 0 ......
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