HBx致肝细胞癌分子机制的研究进展
乙型肝炎病毒;乙型肝炎病毒x;凋亡;细胞增殖;肝细胞肝癌,程斌,林松挺,杨玉珍,通讯作者:,AdvancementonmolecularmechanismofhepatitisBvirusXinducedhepatocellularcarcinoma,Bi
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程斌, 林松挺, 杨玉珍, 华中科技大学同济医学院附属同济医院消化内科 湖北省武汉市 430030
国家自然科学基金资助项目, No. 30570821
通讯作者: 杨玉珍, 430030, 湖北省武汉市解放大道1095号, 华中科技大学同济医学院附属同济医院消化内科.
yzyang@tjh.tjmu.edu.cn
电话: 027-83663612 传真: 027-83646605
收稿日期: 2007-03-22 接受日期: 2007-04-28
Advancement on molecular mechanism of hepatitis B virus X induced hepatocellular carcinoma
Bin Cheng, Song-Ting Lin, Yu-Zhen Yang
Bin Cheng, Song-Ting Lin, Yu-Zhen Yang,Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Supported by:National Natural Science Foundation of China, No. 30570821
Correspondence to:Yu-Zhen Yang, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Street, Wuhan 430030, Hubei Province, China. yzyang@tjh.tjmu.edu.cn
Received:2007-03-22 Accepted:2007-04-28
Abstract
Chronic infection of Hepatitis B Virus (HBV) is one of the major causes of hepatocellular carcinoma (HCC) in our country. Some studies in vivo and in vitro found that hepatitis B virus X (HBx) can induce hepatocellular malignant transformation; also it has become the hot point in the research concerning the mechanism of hepatitis B-related hepatocellular carcinoma at present. Recently, some research on the interaction between HBx and tumor suppressor gene p73 which was a new member of p53 family, p16 and p21, etc. and the influence of HBx on malignant transformation of hepatocellular has achieved preliminary results, but their relations are complicated. This ever in-depth study will help to reveal the molecular mechanism of HBx induced hepatocellular carcinoma, and it has great significance to explore the prevention and cure strategy of hepatitis B-related liver cancer.
Key Words: Hepatitis B virus; Hepatitis B virus X; Apoptosis; Cell proliferation; Hepatocellular carcinoma ......
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