CEBPs及其调节的基因与大鼠肝再生相关性分析
部分肝切除;大鼠基因组2302.0芯片;CCAAT增强子结合蛋白;肝再生相关基因,王望,徐存拴,陈晓光,王望,通讯作者:,CorrelationanalysisofCCAAT,enhancer-bindingproteinsandtheir
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王望, 徐存拴, 河南师范大学生命科学学院 河南省新乡市 453007
陈晓光, 河南省科技部共建细胞分化调控重点实验室 河南省新乡市 453007
王望, 河南师范大学生命科学学院细胞生物学专业在读硕士研究生, 主要从事肝再生分子机制的研究.
通讯作者: 徐存拴, 453007, 河南省新乡市建设东路46号, 河南师范大学生命科学学院. xucs@x263.net
电话: 0373-3326001
收稿日期: 2007-04-24 接受日期: 2007-05-10
Correlation analysis of CCAAT/enhancer-binding proteins and their regulated genes with rat liver regeneration
Wang Wang, Xiao-Guang Chen, Cun-Shuang Xu
Wang Wang, Cun-Shuang Xu,Life Science College of He’nan Normal University, Xinxiang 453007, He’nan Province, China
Xiao-Guang Chen,Key Laboratory of Cell Differentiation and Regulation Co-construction from Science and Technology Department of He’nan Province, Xinxiang 453007, He’nan Province, China
Correspondence to:Cun-Shuang Xu, Life Science College of He’nan Normal University, 46 Jianshe East Road, Xinxiang 453007, He’nan Province, China. xucs@ x263.net
Received:2007-04-24 Accepted:2007-05-10
Abstract
AIM: To explore the effects on transcription levels of CCAAT/enhancer-binding proteins (CEBP) genes and genes regulated in liver regeneration (LR).
METHODS: CEBP family transcription factors correlated with LR were input into the websites of NCBI (www.ncbi.nlm.nih.gov) and RGD (rgd.mcw.edu). Documents related to the transcription functions of CEBP family transcription factors were located and the CEBP family downstream target genes in human, rat and mice obtained. The human and mice non-repeated genes in rat genes were screened out; the results were confirmed by comparison by Rat Genome 230 2.0 chip examination. Twice up-regulated and down-regulated genes were regarded as significantly changed rat homologous genes. The Rat Genome 230 2.0 chips were used to detect the expressions of the above genes in rat RL. Genes correlated with liver regeneration were confirmed by comparison in a true and false operation.
RESULTS: Twenty-seven genes correlated with LR, 11 of which were up-regulated, 6 down-regulated, and 10 that were up-regulated at certain time points but down-regulated at others ......
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