上消化道间叶源性肿瘤临床病理特征46例
上消化道间叶源性肿瘤;胃肠道间质瘤;平滑肌瘤;神经鞘瘤;免疫组化,丁芳,程斌,谢华平,赵秋,杨玉珍,通讯作者:,Clinicalandpathologicalcharacteristicsofuppergastrointestinalmesenchymalt
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丁芳, 程斌, 谢华平, 赵秋, 杨玉珍, 华中科技大学同济医学院附属同济医院消化内科 湖北省武汉市 430030
通讯作者: 程斌, 430030, 湖北省武汉市解放大道1095号, 华中科技大学同济医学院附属同济医院消化内科. bcheng@tjh.tjmu.edu.cn
电话: 027-83663585 传真: 027-83662831
收稿日期: 2007-02-26 修回日期: 2007-07-15
Clinical and pathological characteristics of upper gastrointestinal mesenchymal tumors: An analysis of 46 cases
Fang Ding, Bin Cheng, Hua-Ping Xie, Qiu Zhao, Yu-Zhen Yang
Fang Ding, Bin Cheng, Hua-Ping Xie, Qiu Zhao, Yu-Zhen Yang, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Bin Cheng, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. bcheng@tjh.tjmu.edu.cn
Received: 2007-02-26 Revised: 2007-07-15
Abstract
AIM: To study the clinical, pathological and immunohistochemical characteristics of upper gastrointestinal mesenchymal tumors (GIMTs), so as to provide guidance for clinical diagnosis and treatment.
METHODS: Forty-six cases of upper GIMT were clinically diagnosed by endoscopic ultrasonography (EUS). The samples obtained by surgery or endoscopic mucosal resection were observed by pathological sectioning and staining. The expression of CD117, CD34, smooth muscle antibodies (SMA) and S-100 was assayed by immunohistochemical staining.
RESULTS: Twenty-four of the 46 GIMTs were esophagus mesenchymal tumors, 5 of which were stromal tumors (20.8%) and 19 were leiomyomas (79.2%). Twenty-two of the 46 tumors were gastric mesenchymal tumors, which included 20 stromal tumors (90.9%), 1 leiomyoma and 1 neurilemmoma. Twenty-one of the 25 upper gastrointestinal stromal tumors were CD117 positive (84%) and 24 were CD34 positive (84%). SMA and S-100 were expressed only in leiomyoma and neurilemmoma, respectively ......
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