高脂血症和高脂血症性脂肪肝大鼠肾上腺髓质素2的变化
肾上腺髓质素2;高脂血症;高脂血症性脂肪肝;大鼠;放射免疫法,张玉青,毛孙忠,吴小脉,黄萍,范小芳,龚永生,黄卡特,通讯作者:,Changesinadrenomedullin2inratswithhyperlipidemiaandhyperli
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张玉青, 毛孙忠, 吴小脉, 黄萍, 范小芳, 龚永生, 温州医学院机能实验教学中心 浙江省温州市 325035
黄卡特, 温州医学院附属第一医院病理室 浙江省温州市 325000
温州医学院科技发展基金资助项目, No. XNK04046
通讯作者: 龚永生, 325035, 温州市高教园区温州医学院机能实验教学中心, 肺心病研究室. fxbwzmc@126.com
电话: 0577-86699521 传真: 0577-86699521
收稿日期: 2007-06-18 修回日期: 2007-07-23
Changes in adrenomedullin 2 in rats with hyperlipidemia and hyperlipidemic fatty liver
Yu-Qing Zhang, Ka-Te Huang, Sun-Zhong Mao, Xiao-Mai Wu, Ping Huang, Xiao-Fang Fan, Yong-Sheng Gong
Yu-Qing Zhang, Sun-Zhong Mao, Xiao-Mai Wu, Ping Huang, Xiao-Fang Fan, Yong-Sheng Gong,Teaching Center of Functional Experiment, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China
Ka-Te Huang, Department of Pathology, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Supported by: the Scientific Development Foundation of Wenzhou Medical College, No. XNK04046
Correspondence to: Yong-Sheng Gong, Teaching Center of Functional Experiment, Institute of Cor Pulmonale, Wenzhou Medical College, University Town, Wenzhou 325035, Zhejiang Province, China. fxbwzmc@126.com
Received: 2007-06-18 Revised: 2007-07-23
Abstract
AIM: To investigate changes in adrenomedullin 2/intermedin (ADM2/IMD) in plasma and hepatic tissues of rats with hyperlipidemia and its possible role in the development of hyperlipidemic fatty liver.
METHODS: Sixteen male Sprague–Dawley rats were randomly divided into normal control and hyperlipidemia model groups (n = 8 each). The model was established by feeding a high-fat diet for 4 wk. Liver histology, liver index (liver weight/body weight), liver function alanine aminotransferase (ALT) and alkaline phosphatase (AKP) and blood lipids were assayed. The levels of ADM2/IMD in plasma and liver were measured by radioimmunoassay.
RESULTS: Body and liver weights and liver index increased in the hyperlipidemia model group compared with controls (P < 0 ......
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