Glypican-3蛋白在肝细胞癌患者血清和组织中的表达及意义
肝细胞癌;Glypican-3;基因表达;诊断,缪辉来,温继育,陈念平,陈明,包仕廷,谢贵林,缪辉来,通讯作者:,Glypican-3proteinexpressioninserumandtissuesanditsclinical
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缪辉来, 温继育, 陈念平, 陈明, 包仕廷, 广东医学院附属医院肝胆外科 广东省湛江市 524001
谢贵林, 宁波市第二人民医院 浙江省宁波市 315000
缪辉来, 1995年广东医学院本科毕业, 2001年广东医学院硕士研究生毕业, 副教授, 副主任医师. 主要从事肝胆疾病的基础和临床研究.
广东省第二批科学事业费计划项目, No. 2004B30301001
湛江市科技招标项目, No. 20040025
通讯作者: 缪辉来, 广东省湛江市霞山区人民大道南57号, 广东医学院附属医院肝胆外科. miaohuilai@tom.com
电话: 0759-2387417 传真: 0759-2231754
收稿日期: 2006-12-10 修回日期: 2007-07-23
Glypican-3 protein expression in serum and tissues and its clinical significance in hepatocellular carcinoma
Hui-Lai Miao, Gui-Lin Xie, Ji-Yu Wen, Nian-Ping Chen, Ming Chen, Shi-Ting Bao
Hui-Lai Miao, Ji-Yu Wen, Nian-Ping Chen, Ming Chen, Shi-Ting Bao, Department of Hepatobiliary Surgery, the Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China
Gui-Lin Xie, the Second People’s Hospital of Ningbo City, Ningbo 315000, Zejiang Province, China
Supported by: the Second Group of Scientific Project of Guangdong Province, No. 2004B30301001 and the Technological Biding Program of Zhanjiang City, No. 20040025
Correspondence to: Hui-Lai Miao, Department of Hepatobiliary Surgery, the Affiliated Hospital of Guangdong Medical College, 57 Renmin Street, Zhanjiang 524001, Guangdong Province, China. miaohuilai@tom.com
Received: 2006-12-10 Revised: 2007-07-23
Abstract
AIM: To investigate glypican-3 (GPC3) protein expression and its clinical significance in serum and tissues in hepatocellular carcinoma (HCC).
METHODS: Serum and tissues from 27 patients with HCC and 28 with benign liver disease were collected the day before operation. Expression of GPC3 in serum was detected by Western blotting, and expression in tissues was detected by immunohistochemistry.
RESULTS: In the 27 patients with HCC, GPC3 expression in the HCC, paracarcinomatous and non-tumor liver tissues was 81.5, 0 and 0%, respectively (HC: 23 ......
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