H pylori感染及根除对慢性糜烂性胃炎患者IL-18水平的影响
慢性糜烂性胃炎;Hpylori感染;IL-18;疗效,Hpylori感染及根除对慢性糜烂性胃炎患者IL-18水平的影响,张卫平,朱金水,王如华,孙群,张强,陈尼维,张卫平,通讯作者:,EffectsofHelicobacterpyloriinfectionanditseradicationonI
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张卫平, 朱金水, 王如华, 孙群, 张强, 陈尼维, 上海交通大学附属第六人民医院消化科 上海市 200233
张卫平, 硕士生, 研究方向胃癌及癌前疾病的基础与临床.
通讯作者: 朱金水, 200233, 上海交通大学附属第六人民医院消化科. zhujs1803@hotmail.com
电话: 021-64369181
收稿日期: 2007-05-29 修回日期: 2007-07-26
Effects of Helicobacter pylori infection and its eradication on IL-18 level in chronic erosive gastritis patients
Wei-Ping Zhang, Jin-Shui Zhu, Ru-Hua Wang, Qun Sun, Qiang Zhang, Ni-Wei Chen
Wei-Ping Zhang, Jin-Shui Zhu, Ru-Hua Wang, Qun Sun, Qiang Zhang, Ni-wei Chen, Department of Gastroenterology, Shanghai Sixth People’ Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Correspondence to: Professor Jin-Shui Zhu, Department of Gastroenterology, Shanghai Sixth People’ Hospital, Shanghai Jiaotong University, Shanghai 200233, China. zhujs1803@hotmail.com
Received: 2007-05-29 Revised: 2007-07-26
Abstract
AIM: To explore the effects of Helicobacter pylori infection and its eradication on Interleukin-18 (IL-18) level in patients with chronic erosive gastritis, and to detect levels of H pylori IgG antibody before and after eradication.
METHODS: Sixty patients with chronic gastritis were randomly divided into two groups: chronic erosive gastritis (40 cases, group A) and chronic superficial gastritis (20 cases, group B). Group A patients who were H pylori-positive received triple therapy [20 mg omeprazole (Losec) plus 500 mg clarithromycin and 1000 mg amoxicilin, twice daily) for 1 week; while those positive for H pylori in group B were treated orally with only 20 mg omeprazole once daily until the end of week 4. Gastric endoscopy and 13C breath testing were performed 1 mo after anti-H pylori therapy. CagA-IgG, VacA-IgG, Uresses-IgG and H pylori IgG antibody, IL-18 were detected by Western blotting and ELISA, respectively.
RESULTS: The levels of IL-18 were significantly different between groups A and B (267.18 ± 148 ......
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