HBV感染后外周血CD4+CD25+Foxp3+调节性T细胞与疾病进展的相关性
CD4+CD25+Foxp3+调节性T细胞;乙型肝炎病毒;流式细胞仪,HBV感染后外周血CD4+CD25+Foxp3+调节性T细胞与疾病进展的相关性,周立平,陈昕,巴静,赵连爽,李异玲,通讯作者:,CorrelationbetweenexpressionofCD4+CD25+Foxp3+regul
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周立平, 陈昕, 巴静, 赵连爽, 李异玲, 中国医科大学附属第一医院 辽宁省沈阳市 110001
辽宁省教育厅高等学校科研项目, No. 05L548
通讯作者: 李异玲, 110001, 辽宁省沈阳市, 中国医科大学附属第一医院消化科. zhouliping750825@163.com
电话: 024-83282164
收稿日期: 2007-01-21 修回日期: 2007-07-17
Correlation between expression of CD4+CD25+Foxp3+ regulatory T cells and progression of hepatitis B virus infection
Li-Ping Zhou, Xin Chen, Jing Ba, Lian-Shuang Zhao, Yi-Ling Li
Li-Ping Zhou, Xin Chen, Jing Ba, Lian-Shuang Zhao, Yi-ling Li, The First Αffiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
Supported by: The Scientific Research Project for Universities of Education Department of Liaoning Province, No. 05L548
Correspondence to: Yi-Ling Li, the Department of Gastroenterology, China Medical University, Shenyang 110001, Liaoning Province, China. zhouliping750825@163.com
Received: 2007-01-21 Revised: 2007-07-17
Abstract
AIM: To investigate the correlation between progression of hepatitis B virus (HBV) infection and expression of CD4+CD25+Foxp3+ regulatory T cells.
METHODS: One hundred and thirty-six HBV-infected patients and 40 healthy controls were selected. CD4+CD25+Foxp3+ regulatory T cells expressing was detected by flowcytometry, clinical data of HBV infected patients was considered.
RESULTS: Expression of CD4+CD25+Foxp3+ regulatory T cells in HBV-infected patients increased markedly compared with that in healthy controls (7.48 ± 1.03% vs 3.58 ± 0.71%, P < 0.01). There was also a significant difference chronic hepatitis B compared with chronic severe hepatitis B (6.55 ± 1.26% vs 8.65 ± 2.58%, P < 0.05). The log value of HBV load correlated positively with the expression of CD4+CD25+Foxp3+ regulatory T cells (r = 0 ......
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