华夏小葱制剂对脂肪肝大鼠脂质代谢和组织形态学的影响
华夏小葱制剂;脂肪肝;形态学;脂质代谢;全自动生化分析仪;透视电镜,张介眉,郝建军,时昭红,常青,邴飞虹,通讯作者:,EffectsofapreparationofChineseAlliumfistulosumLonthemorphologya
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张介眉, 郝建军, 时昭红, 武汉市中西医结合医院 湖北省武汉市 430022
常青, 邴飞虹, 湖北中医学院中药研究所 湖北省武汉市 430061
湖北省卫生科研基金项目, No. 2006-63
通讯作者: 张介眉, 430022, 湖北省武汉市中山大道215号, 武汉市中西医结合医院院长办公室. zhangjiemei88@126.com
电话: 027-85332516 传真: 027-85332516
收稿日期: 2007-02-07 修回日期: 2007-07-17
Effects of a preparation of Chinese Allium fistulosum L on the morphology and metabolism of lipids in fatty liver rats
Jie-Mei Zhang, Jian-Jun Hao, Shao-Hong Shi, Qing Chang, Fei-Hong Bing
Jian-Jun Hao, Jie-Mei Zhang, Shao-Hong Shi, Wuhan Integrated Hospital of Traditional Chinese Medicine and Western Medicine, Wuhan 430022, Hubei Province, China
Qing Chang, Fei-Hong Bing, Institute of Traditional Chinese Medicine, College of Traditional Chinese Medicine in Hubei Province, Wuhan 430061, Hubei Province, China
Supported by: the Research Foundation of Public Health of Hubei Province, No. 2006-63
Correspondence to: Jie-Mei Zhang, Wuhan Integrated Hospital of Traditional Chinese Medicine and Western Medicine, 215 Zhongshan Road, Wuhan 430022, Hubei Province, China. zhangjiemei88@126.com
Received: 2007-02-07 Reviesd: 2007-07-17
Abstract
AIM: To study the preventive and therapeutic effects of a preparation of Chinese Allium fistulosum L (PCAL) on fatty liver rats.
METHODS: Sixty sprague–dawley rats were randomly divided into six groups; a blank control group (n = 10), model control group (n = 10), low-, medium- and high-dose PCAL (PCAL low, PCAL medium and PCAL high, respectively, n = 10 in each group), and a Dongbaogantai group (n = 10). The blank control group was given water and food. Other groups were fed with a high-fat diet, given water with 15% ethanol, and treated with a small dose of carbon tetrachloride (CCl4) hypodermically once a week to establish the fatty liver model. All animals were sacrificed after 8 wk. Plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB), globulin (GLO), and A/G (albumin/globulin) were determined by an automatic biochemistry analyzer ......
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