蛋白芯片技术对肝细胞癌组织蛋白谱的建立及标志蛋白的筛选
基质辅助激光解吸附电离;肝细胞癌;组织蛋白谱,李冬,张建中,郑燕华,纪小龙,舒清明,范丽娜,尤红,李享春,通讯作者:,Usingproteinchiptechnologytoscreenfortissueproteomicprofile
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李冬, 张建中, 郑燕华, 中国人民解放军306医院病理科 北京市 100101
纪小龙, 舒清明, 范丽娜, 中国人民解放军武警总医院病理科 北京市 100080
尤红, 北京友谊医院肝病研究中心 北京市100053
李享春, 中国人民解放军装备指挥技术学院士官系门诊部 北京市 102249
李冬, 2002年毕业于第四军医大学, 2004-07/2007-06于航天医学研究所攻读医学硕士, 主要从事航天分子病理学的
研究.
通讯作者: 张建中, 100101, 北京市安翔北路9号, 中国人民解放军306医院病理科. zhangjz55@sina.com
电话: 010-66356237 传真: 010-64871261
收稿日期: 2007-04-14 修回日期: 2007-07-21
Using protein chip technology to screen for tissue proteomic profiles and tumor markers in hepatocellular carcinoma
Dong Li, Jian-Zhong Zhang, Yan-Hua Zheng, Xiao-Long Ji, Hong You, Qing-Ming Shu, Li-Na Fan, Xiang-Chun Li
Dong Li, Jian-Zhong Zhang, Yan-Hua Zheng, Department of Pathology, 306 Hospital of Chinese PLA, Beijing 100101, China
Xiao-Long Ji, Qing-Ming Shu, Li-Na Fan, Department of Pathology, General Hospital of Armed Police Force of Chinese PLA, Beijing 100080, China
Hong You, Research Center of Liver Disease, Beijing Friendship Hospital, Beijing 100053, China
Xiang-Chun Li, Department of Sergeant, The Academy of Equipment Command and Technology of Chinese PLA, Beijing 102249, China
Correspondence to: Jian-Zhong Zhang, Department of Pathology, 306 Hospital of Chinese PLA, 9 Anxiang North Road, Beijing 100101, China. zhangjz55@sina.com
Received: 2007-04-14 Revised: 2007-07-21
Abstract
AIM: To use the surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technique to screen for tissue biomarkers in patients with hepatocellular carcinoma (HCC), but with different clinicopathological features.
METHODS: Proteomic spectra were examined and analyzed by mass spectroscopy in 44 cases, including 26 specimens of HCC tissue that had been pathologically confirmed in patients aged 34–68 years, and 18 specimens of liver cirrhosis tissue in patients aged 38–70 years. The spectra obtained were analyzed using the biomarker wizard system, and the biomarkers were defined by searching www ......
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