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编号:11495308
新辅助放化疗对中晚期食管鳞癌病理分期及预后的影响
http://www.100md.com 2007年8月8日 曹秀峰, 王 山, 吴必超, 黄志华, 朱海文, 王和明, 黄水清, 朱 斌,
食管肿瘤;新辅助放化疗;病理分期;预后,曹秀峰,王和明,黄水清,朱斌,纪律,肖建,王山,吴必超,黄志华,朱海文,通讯作者:,Effectsofneoadjuvantradiochemotherapyonpathologicalstageandpr
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     曹秀峰, 王和明, 黄水清, 朱斌, 纪律, 肖建, 南京医科大学附属南京第一医院肿瘤中心 江苏省南京市 210006

    王山, 吴必超, 黄志华, 朱海文, 江苏省盐城市肿瘤医院 江苏省盐城市 224002

    曹秀峰, 胸外科主任医师, 肿瘤学研究员, 外科学教授, 主要从事消化道肿瘤以手术为主的综合治疗及早诊早治规范化模式研究.

    通讯作者: 曹秀峰, 210006, 江苏省南京市长乐路68号, 南京医科大学附属南京第一医院肿瘤中心. cxf551101@sina.com

    电话: 025-52271474

    收稿日期: 2007-04-19 修回日期: 2007-07-23

    Effects of neoadjuvant radiochemotherapy on pathological stage and prognosis of middle and advanced esophageal carcinoma

    Xiu-Feng Cao, Shan Wang, Bi-Chao Wu, Zhi-Hua Huang, Hai-Wen Zhu, He-Ming Wang, Shui-Qing Huang, Bing Zhu, Lv Ji, Jian Xiao

    Xiu-Feng Cao, He-Ming Wang, Shui-Qing Huang, Bing Zhu, Lv Ji, Jian Xiao, Oncology Center of Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, Jiangsu Province, China

    Shan Wang, Bi-Chao Wu, Zhi-Hua Huang, Hai-Wen Zhu, Yancheng Tumor Hospital, Yancheng 224002, Jiangsu Province, China

    Correspondence to: Xiu-Feng Cao, Oncology Center of Nanjing First Hospital Affiliated to Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu Province, China. cxf551101@sina.com

    Received: 2007-04-19 Revised: 2007-07-23

    Abstract

    AIM: To evaluate the effects of neoadjuvant radiochemotherapy on the pathological stage and prognosis of middle and advanced esophageal carcinoma.

    METHODS: Between January 1991 and December 2000, 473 patients with middle and advanced esophageal carcinoma were randomly divided into four groups; neoadjuvant radiotherapy (n = 118), neoadjuvant chemotherapy (n = 119), neoadjuvant radiochemotherapy (n = 118) and control (surgery alone) (n = 118). The differences in resection rates, pathological stage, treatment-related complications and survival rates were statistically analyzed.

    RESULTS: The data showed that the radical resection rate for patients in the radiotherapy, chemotherapy and radiochemotherapy groups was increased compared with that of the control group (97 ......

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