TFF2在幽门螺杆菌感染胃体部黏膜中的表达
三叶因子2;幽门螺杆菌;胃体腺黏膜;颈黏液细胞;假幽门腺化生,金仁顺,朴东明,方贞花,金仁顺,通讯作者:,Expressionoftrefoilfactorfamily2infundicglandswithHelicobacterpylorii
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金仁顺, 朴东明, 延边大学附属医院病理科 吉林省延吉市 133000
方贞花, 吉林省延吉市医院消化内科 吉林省延吉市 133000
金仁顺, 副主任医师, 医学博士, 硕士研究生导师, 主要从事肿瘤病理研究.
吉林省教育厅科技计划项目, No. 2006-10
通讯作者: 金仁顺, 133000, 吉林省延吉市局子街1327号, 延边大学附属医院病理科. rsjin@163.com
电话: 0433-2660121
收稿日期: 2007-04-05 修回日期: 2007-07-28
Expression of trefoil factor family 2 in fundic glands with Helicobacter pylori infection
Ren-Shun Jin, Zhen-Hua Fang, Dong-Ming Piao
Ren-Shun Jin, Dong-Ming Piao,Department of Pathology, Affiliated Hospital to Yanbian University, Yanji 133000, Jilin Province, China
Zhen-Hua Fang,Department of Gastroenterology, Hospital of Yanji City, Yanji 133000, Jilin Province, China
Supported by:the Science and Technology Planning Project of Education Department of Jilin Province, No. 2006-10
Correspondence to:Ren-Shun Jin, 133000, Department of Pathology, Hospital of Yanbian University, 1327 Juzi Street, Jilin Province. China. rsjin@163.com
Received:2007-04-05 Revised:2007-07-28
Abstract
AIM: To investigate the protein expression of the trefoil factor family 2 (TFF2) in fundic glands with Helicobacter pylori infection.
METHODS: Protein expression of TFF2 was detected by immunohistochemistry in paraffin-embedded samples from 29 (92 blocks) surgical specimens from five patients gastric ulcer and 24 with gastric carcinoma.
RESULTS: Expression of TFF2 was found in mucous neck cells and cells with pseudopylori gland metaplasia. Positive cells were distributed above the 1/2 to 2/3 portions of fundic glands in normal gastric mucosa. The ratio of TFF2-positive cells in the basal portion of the fundic glands was 18.0, 42.9 and 90.5% in mild, moderate and severe glandular atrophy, respectively, and these differences were significant (P < 0.01).
CONCLUSION: H pylori infection increases the expression of TFF2 in deeper parts of the fundic gland, and is also associated with the degree of glandular atrophy ......
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