肝病患者血清血管紧张素转化酶活性变化的临床意义
血管紧张素转化酶;病毒性乙型肝炎;凝血酶原活动度,张剑平,魏红山,孙继云,肖凡,徐道振,成军,张毅,通讯作者:,Clinicalsignificanceofserumangiotensin-convertingenzymechangesinp
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张剑平, 魏红山, 孙继云, 肖凡, 徐道振, 成军, 北京地坛医院传染病研究所 北京市 100011
张毅, 北京中医药大学基础医学院 北京市 100029
通讯作者: 张剑平, 100011, 北京市东城区安外大街地坛公园13号, 北京地坛医院传染病研究所. zhjp2358@126.com电话: 010-64211031-2358 传真: 010-64281540
收稿日期: 2007-03-30 修回日期: 2007-08-03
Clinical significance of serum angiotensin-converting enzyme changes in patients with liver disease
Jian-Ping Zhang, Hong-Shan Wei, Ji-Yun Sun, Fan Xiao, Yi Zhang, Dao-Zhen Xu, Jun Cheng
Jian-Ping Zhang, Hong-Shan Wei, Ji-Yun Sun, Fan Xiao, Dao-Zhen Xu, Jun Cheng, Institute of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China
Yi Zhang, Basic Medicine College, Beijing University of Chinese Medicine, Beijing 100029, China
Correspondence to: Jian-Ping Zhang, Institute of Infectious Diseases, Beijing Ditan Hospital, 13 Ditan Park, Anwai Street, Beijing 100011, China. zhjp2358@126.com
Received: 2007-03-30 Revised: 2007-08-03
Abstract
AIM: To discuss the clinical significance of changes in angiotensin-converting enzyme (ACE) in different sub-types of hepatitis B and in healthy controls.
METHODS: A Hitachi 7180 fully automatic biochemical analyzer was used to detect ACE activity and to measure prothrombin activity (PTA) in samples from the two groups.
RESULTS: Serum ACE activity among the different clinical sub-types of hepatitis B was as follows: control group (24.71 ± 9.43 μmol/L); obstruct jaundice (28.75 ± 13.04 μmol/L); liver cirrhosis combined with liver cancer after hepatitis B (43.81 ± 15.01 μmol/L); acute hepatitis B (46.97 ± 17.40 μmol/L); chronic hepatitis B (53.01 ± 16.38 μmol/L); liver cirrhosis after hepatitis B (72.29 ± 20.26 μmol/L); and chronic severe hepatitis B (74.12 ± 21.04 μmol/L). Serum ACE activity in patients with liver cirrhosis after hepatitis B was significantly higher than that in those with liver cirrhosis combined with liver cancer ......
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