HIF-1α及耐药蛋白在胰腺癌中的表达及相关性分析
胰腺癌;缺氧诱导因子-1α;化疗耐药;多药耐药基因;凋亡,孙晶,曹俊,江弢,张放,黄陈,裘正军,孙晶,通讯作者:,ExpressionandcorrelationofHypoxiainducibleFactor1αanddrug-resis
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孙晶, 曹俊, 江弢, 张放, 黄陈, 裘正军, 上海交通大学附属第一人民医院普外科 上海市 200080
孙晶, 上海交通大学附属第一人民医院普外科住院医师, 主要从事消化道肿瘤的分子生物学研究.
上海市卫生局科技发展基金项目, No. 024012
通讯作者: 裘正军, 200080, 上海市海宁路100号, 上海交通大学附属第一人民医院普外科. qiuwryb@online.sh.cn
电话: 021-63240090-3092
收稿日期: 2007-04-16 修回日期: 2007-08-06
Expression and correlation of Hypoxia inducible Factor 1α and drug-resistance-correlated proteins in human pancreatic carcinoma
Jing Sun, Jun Cao, Tao Jiang, Fang Zhang, Chen Huang, Zheng-Jun Qiu
Jing Sun, Jun Cao, Tao Jiang, Fang Zhang, Chen Huang, Zheng-Jun Qiu,Department of General Surgery, The First Affiliated People’s Hospital of Shanghai Jiaotong University, Shanghai 200080, China
Supported by:the Scientific Development Foundation of Shanghai Health Bureau, No. 024012
Correspondence to:Dr. Zheng-Jun Qiu, Department of General Surgery, The First Affiliated People’s Hospital of Shanghai Jiaotong University, 100 Haining Road, Shanghai 200080, China. qiuwryb@online.sh.cn
Received:2007-04-16 Revised:2007-08-06
Abstract
AIM: To investigate the expression of Hypoxia inducible Factor 1α(HIF-1α) and the drug-resistance-correlated indexes P-glycoprotein (P-Gp), Bcl-XL and Bax, and the relationship between HIF-1α and resistance to chemotherapy in human pancreatic carcinoma.
METHODS: Protein expression of HIF-1α, P-Gp, Bcl-XL and Bax in pancreatic tissues from 34 radically resected specimens of pancreatic carcinoma was detected by immunohistochemical staining.
RESULTS: The protein expression rates of HIF-1α, P-Gp, Bcl-XL and Bax in pancreatic carcinoma were 26/34 (76.5%), 28/34 (82.4%), 30/34 (88.2%) and 26/34 (76.5%), respectively. There were positive correlations between the positivity rates of HIF-1α and P-Gp, Bcl-XL and Bax (r = 0.471, P = 0.005; r = 0.443, P = 0.009; r = 0.510, P = 0.002).
CONCLUSION: HIF-1α, P-Gp, Bcl-XL and Bax were over-expressed in human pancreatic carcinoma tissues ......
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