血清转化生长因子β1水平在慢性乙型肝炎与乙型肝炎肝硬化患者中差异的意义
转化生长因子β1;乙型病毒性肝炎;纤维化;炎症;酶联免疫吸附,何泽宝,朱坚胜,曾文新,陈华忠,王庚歌,方浩,陈智,朱敏,何泽宝,通讯作者:,Significanceoftheserumleveloftransformin
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何泽宝, 朱坚胜, 曾文新, 陈华忠, 王庚歌, 方浩, 台州医院感染科 浙江省临海市 317000
陈智, 浙江大学医学院附属第一医院传染病研究所卫生部传染病重点实验室 浙江省杭州市 310003
朱敏, 浙江省台州医院中心实验室 浙江省临海市 317000
何泽宝, 副主任医师, 主要从事肝纤维化的研究.
通讯作者: 朱坚胜, 317000, 浙江省临海市西门街150号, 浙江省台州医院感染科. zhujs@tzhospital.com
电话: 0576-85199655
收稿日期: 2007-05-26 修回日期: 2007-09-27
Significance of the serum level of transforming growth factor β1 and its difference in patients with chronic hepatitis B and HBV-induced hepatic cirrhosis
Ze-Bao He, Jian-Sheng Zhu, Zhi Chen, Min Zhu, Wen-Xin Zeng, Hua-Zhong Chen, Geng-Ge Wang, Hao Fang
Ze-Bao He, Jian-Sheng Zhu, Wen-Xin Zeng, Hua-Zhong Chen, Geng-Ge Wang, Hao Fang, Department of Infectious Disease, Tai Zhou Hospital of Zhejiang Province, Linhai 317000, Zhejiang Province, China
Zhi Chen, Institute of Infectious Diseases, Key Lab of Infection Diseases, Ministry of Public Health, the First Affiliatied Hospital, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Min Zhu, Department of Central Laboratory, Tai Zhou Hospital of Zhejiang Province, Linhai 317000, Zhejiang Province, China
Correspondence to: Jian-Sheng Zhu, Department of Infectious Disease, Tai Zhou Hospital of Zhejiang Province, Linhai 317000, Zhejiang Province, China. zhujs@tzhospital.com
Received: 2007-05-26 Revised: 2007-09-27
Abstract
AIM: To investigate the relationship between the levels of transforming growth factor (TGF) β1 in serum and inflammation, as well as fibrous degeneration of the liver, and the difference in the levels of TGFβ1 in patients between with chronic hepatitis B and HBV-induced hepatic cirrhosis.
METHODS: Four markers of hepatic fibrosis (HA, LN, CIV, PCⅢ) were measured by radioimmunoassay and the serum levels of TGFβ1 were measured by enzyme linked immunosorbent assay (ELISA) in 65 patients with chronic hepatitis B (chronic hepatitis group), 56 patients with HBV-induced hepatic cirrhosis (hepatic cirrhosis group) and 50 health personnel who were negative for HBV markers (control group) ......
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