保留半肝动脉血供的入肝血流阻断法对大鼠肝缺血再灌注损伤的影响
保留半肝动脉血供的入肝血流阻断法;缺血再灌注;肝脏损伤;大鼠,金山,戴朝六,贾昌俊,许永庆,彭志敏,金山,通讯作者:,Effectofhepaticbloodinflowocclusionwithouthemihepaticart
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金山, 戴朝六, 贾昌俊, 许永庆, 彭志敏, 中国医科大学附属盛京医院肝胆外科 辽宁省沈阳市 110004
金山, 2005年中国医科大学附属盛京医院肝胆外科博士, 主要从事肝脏外科临床及基础研究.
美国中华医学基金会(CMB)资助项目, No. 06-837
通讯作者: 戴朝六, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属盛京医院肝胆外科. daicl-sy@tom.com
电话: 024-83955232 传真: 024-83955092
收稿日期: 2007-06-04 修回日期: 2007-10-07
Effect of hepatic blood inflow occlusion without hemihepatic artery control during hepatic ischemia-reperfusion injury in rats
Shan Jin, Chao-Liu Dai, Chang-Jun Jia, Yong-Qing Xu, Zhi-Min Peng
Shan Jin, Chao-Liu Dai, Chang-Jun Jia, Yong-Qing Xu, Zhi-Min Peng,Department of Hepatobiliary Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China
Supported by: the China Medical Board of New York Inc., No. 06-837
Correspondence to: Prof Chao-Liu Dai, Department of Hepatobiliary Surgery, Shengjing Hospital, China Medical University, 36 Sanhao street, Heping District Shenyang 110004, Liaoning Province, China. daicl-sy@tom.com
Received: 2007-06-04 Revised: 2007-10-07
Abstract
AIM: To investigate the effect of hepatic blood inflow occlusion without hemihepatic artery control during hepatic ischemia-reperfusion injury in rats.
METHODS: Ninety-six Wistar rats were randomly divided into the Pringle group (groupⅠ), hemihepatic vascular occlusion group (group Ⅱ) and hepatic blood inflow occlusion without hemihepatic artery control group (group Ⅲ). After 30 min of hepatic vascular occlusion with three methods, the liver blood flow was reperfused. After reperfusion for 1, 2, 6 and 24 hours, we measured serum AST and ALT and liver tissue (superoxide dismutase) SOD, MDA, pathology and apoptosis.
RESULTS: After each period of reperfusion, ALT, AST, MDA and apoptosis rate were significantly lower in groups Ⅱ and Ⅲ than in groupⅠ, but SOD activity was significantly higher. AST, ALT, MDA, SOD and apoptosis rate did not differ significantly between groups Ⅱ and Ⅲ ......
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