抵抗素基因启动子-420C/G多态性与日本高知地区非酒精性脂肪肝炎的相关性
抵抗素;单核苷酸多态性;胰岛素抵抗;非酒精性脂肪肝炎;聚合酶链反应-限制性片断长度多态性,马瑞宏,黄颖秋,西元利治,马瑞宏,通讯作者:,C,Ghomozygotesofresistinsinglenucleotid
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马瑞宏, 黄颖秋, 本溪钢铁(集团)公司总医院消化内科 辽宁省本溪市 117000
西元利治, 高知医科大学消化内科 日本高知市 780-0870
马瑞宏, 2005年佳木斯大学临床医学院消化内科硕士研究生, 2005年赴日本高知医科大学交流学习, 医师, 主要从事非酒精性脂肪肝炎的研究.
通讯作者: 马瑞宏, 117000, 辽宁省本溪市人民路29号, 本溪钢铁(集团)公司总医院消化内科. maruihong120@yahoo.com.cn
电话: 0414-2215138
收稿日期: 2007-08-22 修回日期: 2007-10-04
C/G homozygotes of resistin single nucleotide polymorphism at -420 are associated with non-alcoholic steatohepatitis
Rui-Hong Ma, Ying-Qiu Huang, Sibara Toshiji
Rui-Hong Ma, Ying-Qiu Huang, Department of Gastroenterology, General Hospital of Benxi Iron and Steel Co., Benxi 117000, Liaoning Province, China
Saibara Toshiji, Department of Hepatology and Gastroenterology, Kochi Medical University, Kochi 780-0870, Japan
Correspondence to: Dr. Rui-Hong Ma, Department of Gastroenterology, General Hospital of Benxi Iron and Steel Co., 29 Renmin Road, Benxi 117000, Liaoning Province, China. maruihong120@yahoo.com.cn
Received: 2007-08-22 Revised: 2007-10-04
Abstract
AIM: To investigate the relationship between the C/G genotypes of resistin single nucleotide polymorphism (SNP) at -420 and the development and progression of non-alcoholic steatohepatitis (NASH) in the Kochi area of Japan.
METHODS: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to determine a common polymorphism of the human resistin gene, -420C > G, in 107 controls and 77 patients with NASH. In patients with NASH, 12-hour fasting serum resistin level was determined by enzyme linked immunosorbent assay (ELISA). CT was used to assess liver visceral fat infiltration.
RESULTS: Homozygotes for -420G of the resistin gene were more frequent in NASH patients than in controls (0.552 vs 0.407, P < 0.01). Resistin level was significantly higher in NASH patients homozygous for -420G of the resistin gene than in those with other genotypes (27 ......
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