老年胃癌术后患者118例的预后分析
胃癌;老年患者;预后;多因素分析,张煜,马力文,梁莉,通讯作者:,Prognosticfactorsanalysisof118elderlypostoperativepatientswithgastriccancer,YuZhang,Li-WenMa,LiLia
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张煜, 马力文, 梁莉, 北京大学第三医院肿瘤治疗中心 北京市 100083
张煜, 2006年毕业于北京大学医学部, 硕士, 主要从事肿瘤研究.
通讯作者: 马力文, 100083, 北京市海淀区花园北路49号, 北京大学第三医院肿瘤治疗中心. maliwen@sohu.com
电话: 010-52075516
收稿日期: 2007-07-27 修回日期: 2007-09-27
Prognostic factors analysis of 118 elderly postoperative patients with gastric cancer
Yu Zhang, Li-Wen Ma, Li Liang
Yu Zhang, Li-Wen Ma, Li Liang, Department of Medical Oncology, the Third Hospital of Peking University, Beijing 100083, China
Correspondence to: Li-Wen Ma, Department of Medical Oncology, the Third Hospital of Peking University, 49 Huayuan North Road, Haidian District, Beijing 100083, China. maliwen@sohu.com
Received: 2007-07-27 Revised: 2007-09-27
Abstract
AIM: To study the relationship between clinical characteristics, postoperative chemotherapy and prognosis in elderly patients with gastric cancer.
METHODS: One hundred and eighteen elderly postoperative patients with gastric cancer were retrospectively analyzed from January 1997 to January 2006 in our hospitals, using Kaplan-Meier and Cox regression analysis to evaluate candidate prognosis factors, such as gender, clinical stage, differentiation, invasion depth, lymph node metastasis, distant metastasis, lymph-vascular space invasion, number of surgical resection lymph nodes, tumor residual and postoperative chemotherapy.
RESULTS: In univariate survival analysis, clinical stage, invasion depth, lymph node metastasis, distant metastasis, postoperative chemotherapy and tumor residual were obviously correlated with the prognosis (P < 0.05). In multivariable analysis, postoperative chemotherapy, tumor residual and clinical stage were confirmed to be independent factors (P = 0.000, P = 0.000 and P = 0.002).
CONCLUSION: Postoperative chemotherapy, tumor residual and clinical stage are independent prognostic factors in elderly postoperative gastric cancer patients, with stage Ⅲ and Ⅳ elderly patients that accept postoperative chemotherapy having an obvious survival advantage ......
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