脑肠肽Obestatin与Ghrelin的研究进展
Obestatin;Ghrelin;脑肠肽;受体;生物学功能,唐胜球,江青艳,张永亮,朱晓彤,束刚,高萍,通讯作者:,Researchprogressonbrain-gutpeptideobestatinandghrelin,Sheng-QiuT
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唐胜球, 江青艳, 张永亮, 朱晓彤, 束刚, 高萍, 华南农业大学动物科学学院 广东省广州市 510642
国家自然科学基金资助项目, No. 30471268
国家重点基础研究发展规划(973 计划)项目资助项目, No. 2004CB117500
通讯作者: 江青艳, 510642, 广东省广州市, 华南农业大学动物科学学院. qyjiang@scau.edu.cn
电话: 020-85285469
收稿日期: 2007-09-08 修回日期: 2007-10-25
Research progress on brain-gut peptide obestatin and ghrelin
Sheng-Qiu Tang, Qing-Yan Jiang, Yong-Liang Zhang, Xiao-Tong Zhu, Gang Shu, Ping Gao
Sheng-Qiu Tang, Qing-Yan Jiang, Yong-Liang Zhang, Xiao-Tong Zhu, Gang Shu, Ping Gao, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong Province, China
Supported by: National Natural Science Foundation of China, No. 30471268 and the Special Funds of the National Basic Research Program of China (973 Program), No. 2004CB117500
Correspondence to: Qing-Yan Jiang, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong Province, China. qyjiang@scau.edu.cn
Received: 2007-09-08 Revised: 2007-10-25
Abstract
Obestatin and ghrelin are two important brain–gut peptides that can combine with their receptors and exert important biological functions. Obestatin is a 76–98 amino acid polypeptide segment of proghrelin that binds to the orphan G-protein-coupled receptor GPR39, which can suppress food intake, inhibit jejunal contraction, and decrease body-weight gain. Ghrelin is a 24–51 amino acid peptide segment of proghrelin that binds to receptor GHS-R, which can enhance appetite and body weight, promote the release of GH, and affect cardiovascular and immune functions. Obestatin is regarded as on biological antagonist, or a Yin and Yang activated polypeptide of ghrelin.
Key Words: Obestatin; Ghrelin; Brain-gut peptide; Receptor; Biological functions
Tang SQ, Jiang QY, Zhang YL, Zhu XT, Shu G, Gao P. Research progress on brain–gut peptide obestatin and ghrelin. Shijie Huaren Xiaohua Zazhi 2007; 15(31): 3324-3331 ......
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