血糖变化对糖尿病大鼠胃排空功能与leptin表达的影响
糖尿病;胃轻瘫;胃排空;瘦素,卢静,魏良洲,田字彬,杨振中,通讯作者:,Effectofbloodglucosevariationongastricemptyingandleptinexpressionindiabeticrats,Ji
 |
| 第1页 |
参见附件(838KB，4页)。
卢静, 魏良洲, 田字彬, 青岛大学医学院附属医院消化内科 山东省青岛市 266003
杨振中, 中国航天员科研训练中心 北京市 100094
通讯作者: 魏良洲, 266003, 山东省青岛市, 青岛大学医学院附属医院消化内科. weiliangzhou62@126.com
电话: 0532-82911302
收稿日期: 2007-08-11 修回日期: 2007-10-22
Effect of blood glucose variation on gastric emptying and leptin expression in diabetic rats
Jing Lu, Liang-Zhou Wei, Zi-Bin Tian, Zhen-Zhong Yang
Jing Lu, Liang-Zhou Wei, Zi-Bin Tian, Department of Gastroenterology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
Zhen-Zhong Yang, Astronaut Research and Training Center of China, Beijing 100094, China
Correspondence to: Liang-Zhou Wei, Department of Gastroenterology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China. weiliangzhou62@126.com
Received: 2007-08-11 Revised: 2007-10-22
Abstract
AIM: To investigate the relationship between delayed gastric emptying and gastric leptin expression at different stages of diabetes.
METHODS: Forty Wistar rats were randomly divided into four groups: 1-wk normal control group (NC1 group, n = 6), 4-wk normal control group (NC2 group, n = 6), 1-wk diabetes mellitus group (DM1 group, n = 14), and 4-wk diabetes mellitus group (DM2 group,n = 14). Diabetes was induced by intraperitoneal injection of streptozotocin (STZ). One and 4 wk after STZ injection, gastric emptying was measured by intragastric administration of phenol red, and expression of serum and gastric leptin was detected by radioimmunoassay.
RESULTS: One week after STZ injection, body weight did not differ between the DM1 and NC1 groups. The level of serum leptin in the DM1 group decreased compared with that in the NC1 group (0.6 ± 0.40 μg/L vs 2.9 ± 0.32 μg/L), but gastric emptying (72.07% ± 9.67% vs 33.04% ± 4.07%) and gastric leptin level (11.041 ± 1.422 μg/L vs 8 ......
您现在查看是摘要介绍页，详见PDF附件(838KB，4页)。