胰腺导管内乳头状黏液性肿瘤组织中MUC1, MUC2, MUC5AC和TFF1的表达意义
胰腺肿瘤;导管内乳头状黏液性肿瘤;黏液蛋白;三叶因子1,胰腺导管内乳头状黏液性肿瘤组织中MUC1,MUC2,MUC5AC和TFF1的表达意义,何度,张秀辉,何度,通讯作者:,ExpressionofMUC1,MUC2,MUC5ACandTFF1inintraductalpapillarymuci
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何度, 张秀辉, 四川大学华西医院病理科 四川省成都市 610041
何度, 硕士, 从事肿瘤病理研究.
通讯作者: 张秀辉, 610041, 四川省成都市国学巷37号, 四川大学华西医院病理科. zhangxiuhui1955@126.com
收稿日期: 2007-04-12 修回日期: 2007-10-10
Expression of MUC1, MUC2, MUC5AC and TFF1 in intraductal papillary mucinous neoplasms of the pancreas and its significance
Du He, Xiu-Hui Zhang
Du He, Xiu-Hui Zhang, Department of Pathology, West China Hospital, Chengdu 610041, Sichuan Province, China
Correspondence to: Xiu-Hui Zhang, Department of Pathology, West China Hospital, 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. zhangxiuhui1955@126.com
Received: 2007-04-12 Revised: 2007-10-10
Abstract
AIM: To examine the expression of MUC1, MUC2, MUC5AC and TFF1 in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and its significance.
METHODS: Immunohistochemistry was used to detect the expression of MUC1, MUC2, MUC5AC and TFF1 in nine surgically resected specimens with different histological subtypes of IPMN.
RESULTS: The positive rates of MUC1, MUC2 and MUC5AC in all IPMNs were 44.4%, 66.7% and 100%, respectively. The common expression patterns of MUCs in different histological subtypes were: gastric type (MUC1–, MUC2–, MUC5AC+), intestinal type (MUC1–, MUC2+, MUC5AC+), and oncocytic type (MUC1+, MUC2+, MUC5AC+). Ductal type invasive carcinomas associated with IPMNs were MUC1+, whereas colloid carcinomas were MUC2+. MUC5AC and TFF1 were co-localized in IPMNs, and reduced expression appeared in invasive components. Gastric type IPMNs sometimes merged with other IPMN subtypes, and transition between different epithelia was present, implying that the gastric type might be a precursor of the other subtypes.
CONCLUSION: Different IPMN subtypes have their own MUC expression pattern. MUC1 suggests aggressive behavior, MUC2 is associated with colloid carcinoma, and MUC5AC and TFF1, which were co-expressed, might be protective factors ......
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