苦参碱对四氯化碳所致小鼠慢性肝纤维化肝组织一氧化氮合酶表达的干预及意义
诱生型一氧化氮合酶;肝纤维化;苦参碱;免疫组化,马宁芳,郭晓才,黄宏森,张超,郭晓珍,李叶莉,马宁芳,通讯作者:,Inhibitoryeffectsofmatrineontheexpressionofinduciblenit
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马宁芳, 郭晓才, 广州医学院组织学与胚胎学教研室 广东省广州市 510182
黄宏森, 张超, 郭晓珍, 李叶莉, 广州医学院第一临床学院2004级双语班 广东省广州市 510182
马宁芳，医学博士, 副教授，从事肝脏的基础与临床研究.
广州医学院归国留学启动基金资助项目, No. 2006GD051
通讯作者: 马宁芳, 510182, 广东省广州市, 广州医学院组织学与胚胎学教研室. maningfang@yahoo.com.cn
电话: 020-81340319
收稿日期: 2007-07-04 修回日期: 2007-10-10
Inhibitory effects of matrine on the expression of inducible nitric oxide synthase during hepatic fibrosis induced by carbon tetrachloride in mice
Ning-Fang Ma, Hong-Seng Huang, Chao Zhang, Xiao-Zhen Guo, Ye-Li Li, Xiao-Cai Guo
Ning-Fang Ma, Xiao-Cai Guo, Department of Histology and Embryology, Guangzhou Medical College, Guangzhou 510182, Guangdong Province, China
Hong-Seng Huang, Chao Zhang, Xiao-Zhen Guo, Ye-Li Li, Bilingualism Class, Grade 2004, the First Clinical Institute of Guangzhou Medical College, Guangzhou 510182, Guangdong Province, China
Supported by: the Returned Overseas Foundation of Guangzhou Medical College, No. 2006GD051
Correspondence to: Ning-Fang Ma, Department of Histology and Embryology, Guangzhou Medical College, Guangzhou 510182, Guangdong Province, China. maningfang@yahoo.com.cn
Received: 2007-07-04 Revised: 2007-10-10
Abstract
AIM: To study the effects of matrine on the expression of inducible nitric oxide synthase (iNOS) in carbon tetrachloride (CCl4)-induced liver injury in mice.
METHODS: Fifty mice were randomly divided into four groups: CCl4 group (group A, n = 15), CCl4 + matrine group (group B, n = 15), matrine control group (group C, n = 10), and saline control group (group D, n = 10). Mice in each group were sacrificed at 4 and 8 weeks, and the liver pathology was estimated by hematoxylin and eosin (HE) staining. The expression of iNOS in liver tissues of every group was detected by immunohistochemistry.
RESULTS: The animals in group A at 4 weeks developed slight steatosis and obvious inflammation ......
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