胃癌组织中细胞骨架4.1蛋白家族的表达意义
胃癌;4.1蛋白;免疫组化,许晶晶,陈鲤翔,翟文杰,冯文坡,祁元明,许晶晶,通讯作者:,Expressionandsignificanceofmembraneskeletonprotein4.1singastriccarcinoma,Jing-Ji
 |
| 第1页 |
参见附件(930KB，5页)。
许晶晶, 陈鲤翔, 翟文杰, 冯文坡, 祁元明, 郑州大学生物工程系 河南省郑州市 450001
许晶晶, 主要从事消化系统疾病的病理研究.
河南省医学科技创新人才资助项目, No. 200311201
河南省重点科技攻关资助项目, No. 0495060801
通讯作者: 祁元明, 450001, 河南省郑州市, 郑州大学生物工程系. qym@zzu.edu.cn
电话: 0371-67783329
收稿日期: 2007-06-29 修回日期: 2007-10-12
Expression and significance of membrane skeleton protein 4.1s in gastric carcinoma
Jing-Jing Xu, Li-Xiang Chen, Wen-Jie Zhai, Wen-Po Feng, Yuan-Ming Qi
Jing-Jing Xu, Li-Xiang Chen, Wen-Jie Zhai, Wen-Po Feng, Yuan-Ming Qi, Department of Bioengineering, Zhengzhou University, Zhengzhou 450001, Henan Pro-vince, China
Supported by: the Medical Science and Technique Innovation Talent Project of Henan Province, No. 200311201; and the Tackle Key Problems in Science and Technology Project of Henan Province, No. 0495060801
Correspondence to: Dr. Yuan-Ming Qi, Department of Bioengineering, Zhengzhou University, Zhengzhou 450001, Henan Province, China. qym@zzu.edu.cn.
Received: 2007-06-29 Revised: 2007-10-12
Abstract
AIM: To investigate the expression and signi-ficance of four members (4.1B, 4.1R, 4.1G and 4.1N) of membrane skeleton protein 4.1 family in human gastric carcinoma tissues.
METHODS: Expression of 4.1B, 4.1R, 4.1G and 4.1N was examined by immunohistochemistry (Envision+ assay) in archival paraffin-embedded gastric carcinoma tissues from 104 patients (77 males, 27 females, median age 61.7 years). Each case had detailed clinical data and surgical records. None of the patients were treated by radiotherapy or chemotherapy before surgery.
RESULTS: In gastric carcinoma, the expression of 4.1B, 4.1R, 4.1G and 4.1N was significantly different from that in normal gastric tissue (P < 0.01). The expression of 4.1B, 4.1G and 4.1N was significantly reduced when tumor differentiation became lower, which suggested these three members were significantly correlated with tumor differentiation status (PB < 0 ......
您现在查看是摘要介绍页，详见PDF附件(930KB，5页)。