乙型肝炎病毒基因型、BCP及PC区变异与拉米夫定治疗后HBV DNA反弹的关系
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苏明华, 江建宁, 周元平, 陈茂伟, 刘志红
乙型肝炎病毒;基因型;基因变异;拉米夫定;HBVDNA反弹,乙型肝炎病毒基因型、BCP及PC区变异与拉米夫定治疗后HBVDNA反弹的关系,苏明华,江建宁,陈茂伟,刘志红,周元平,苏明华,通讯作者:,RelationshipofHBVgenotypeandbcpandpcmutationswit
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苏明华, 江建宁, 陈茂伟, 刘志红, 广西医科大学一附院感染性疾病科 广西壮族自治区南宁市 530027
周元平, 广州南方医院 广东省广州市 510000
苏明华, 2006年广西医科大学硕士研究生, 硕士, 副教授, 主要从事病毒性肝炎诊断与治疗的研究.
广西自然科学基金桂科资助项目, No. 0342009
通讯作者: 江建宁, 530027, 广西壮族自治区南宁市, 广西医科大学一附院感染性疾病科. jjianning@163.com
收稿日期: 2007-08-08 修回日期: 2007-09-30
Relationship of HBV genotype and bcp and pc mutations with HBV DNA rebound after lamivudine therapy
Ming-Hua Su, Jian-Ning Jiang, Yuan-Ping Zhou, Mao-Wei Chen, Zhi-Hong Liu
Ming-Hua Su, Jian-Ning Jiang, Mao-Wei Chen, Zhi-Hong Liu, Department of Infectious Diseases, the First Clinical Hospital of Guangxi Medical University, Nanning 530027, Guangxi Zhuangzu Autonomous Region, China
Yuan-Ping Zhou, Nanfang Hospital of Guangzhou, Guangzhou 510000, Guangdong Province, China
Supported by: National Natural Science Foundation of Guangxi, No. 0342009
Correspondence to: Professor Jian-Ning Jiang, Department of Infectious Diseases, the First Clinical Hospital of Guangxi Medical University, Nanning 530027, Guangxi Zhuangzu Autonomous Region, China. jjianning@163.com
Received: 2007-08-08 Revised: 2007-09-30
Abstract
AIM: To investigate the relationship of HBV gene mutations with HBV DNA rebound after lamivudine therapy.
METHODS: Twenty-seven hepatitis B patients with HBV DNA rebound after lamivudine therapy (therapy group) and 19 patients without antiviral therapy (control group) were investigated. HBV genotype was detected by nested PCR with multiple pair primers. Mutations of basal core promoter (BCP) and precore (PC) were identified by PCR gene sequence analysis in sera of 27 patients after HBV DNA rebound, and in sera of 4 patients before therapy in the therapy group and in sera of 19 patients in the control group.
RESULTS: The ratio of BCP (A1762T + G1764A) mutations in serum of patients with HBV DNA rebound was 44.44% (12/27) higher than 26 ......
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