胃癌组织MMP-10和VEGF表达与血管生成的关系
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赵向阳, 施瑞华
基质金-属蛋白酶-10;血管内皮生长因子;胃肿瘤;免疫组化方法,赵向阳,施瑞华,赵向阳,通讯作者:,Expressionofmatrixmetalloproteinase-10andvascularendothelialgrowthfactori
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赵向阳, 施瑞华, 南京医科大学第一附属医院消化内科 江苏省南京市 210029
赵向阳, 南京医科大学在职硕士, 南京市溧水县人民医院消化内科副主任医师, 主要从事胃肠道肿瘤等方面的研究.
江苏省自然科学基金资助项目, No. BK2005153
通讯作者: 施瑞华, 210029, 江苏省南京市, 南京医科大学第一附属医院消化内科. ruihuashi@126.com
电话: 025-83718836-6032
收稿日期: 2007-07-17 修回日期: 2007-10-10
Expression of matrix metalloproteinase-10 and vascular endothelial growth factor in gastric carcinoma and its relationship with angiogenesis
Xiang-Yang Zhao, Rui-Hua Shi
Xiang-Yang Zhao, Rui-Hua Shi, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Supported by: the Natural Science Fund of Jiangsu Province, No. BK2005153
Correspondence to: Rui-Hua Shi, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. ruihuashi@126.com
Received: 2007-07-17 Revised: 2007-10-10
Abstract
AIM: To investigate the expression of matrix metalloproteinase-10 (MMP-10) and vascular endothelial growth factor (VEGF) and microvascular density (MVD) in gastric carcinoma and its relationship with the clinical characteristics of tumors.
METHODS: CD31 was used as the standard of MVD. 60 examples of gastric carcinoma tissue by immunohistochemistry for MMP-10, VEGF and CD31 were investigated, and were compared the results with those in 60 normal tissues.
RESULTS: The expression positive rates for MMP-10 and VEGF in the 60 gastric carcinoma tissues were 81.7% and 76.7%, respectively. They were much higher than those in normal tissue samples (11.7% and 8.3%, respectively). The differences were statistically significant (P < 0.05). The expression of MMP-10 and VEGF was related with MVD, and tumor grade, TNM classification, lymphatic metastasis, and degree of invasion.
CONCLUSION: The high expression of MMP-10 and VEGF in gastric carcinoma is closely related to metastasis of gastric carcinoma and angiogenesis ......
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