中国江苏地区健康人群CFTR基因M470V多态性分析132例
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黄 沁, 丁 炜, 魏睦新
CFTR基因;多态性;M470V基因型,黄沁,丁炜,魏睦新,通讯作者:,PolymorpholismsofM470Vgenotypesofthecysticfibrosistransmembraneconductanceregulato
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黄沁, 丁炜, 魏睦新, 南京医科大学第一附属医院中医科 江苏省南京市 210029
江苏省中医药领军人才基金资助项目, No. 2006-01
通讯作者: 魏睦新, 210029, 江苏省南京市广州路300号, 南京医科大学第一附属医院中医科. weimuxin@njmu.edu.cn
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收稿日期: 2007-07-19 修回日期: 2007-10-20
Polymorpholisms of M470V genotypes of the cystic fibrosis transmembrane conductance regulator gene in 132 healthy people in Jiangsu Province of China
Qin Huang, Wei Ding, Mu-Xin Wei
Qin Huang, Wei Ding, Mu-Xin Wei, Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Supported by: the Key Talents of Traditional Chinese Medicine Foundation from the Government of Jiangsu Province, No. 2006-01
Correspondence to: Dr. Mu-Xin Wei, Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. weimuxin@njmu.edu.cn
Received: 2007-07-19 Revised: 2007-10-20
Abstract
AIM: To investigate the polymorphic backgrounds of the cystic fibrosis trans-membrane conductance regulator gene (CFTR) in Chinese people and the correlation between these polymorphisms and those in Caucasians and other Asian populations.
METHODS: Polymerase chain reaction was used to amplify Exon 10 of the CFTR gene. HphⅠ was used to detect the M470V polymorphism.
RESULTS: The M/V polymorphism at position 470 was similar to that in Caucasians and other Asian populations. The V allele was slightly more frequent than the M allele (50.00% vs 43.94%). The frequency of genotypes MV, VV and MM was 45.5%, 33.3% and 21.21%, respectively.
CONCLUSION: The data on the M470V polymorphism in exon 10, provide genotype information for the CFTR gene.
Key Words: Cystic fibrosis transmembrane conductance regulator gene; Polymorphism; M470V genotypes
Huang Q, Ding W, Wei MX ......
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