Cdk3在结肠癌变过程中的表达及其意义
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黄大毛, 王巍巍, 莫 莉, 冯德元, 颜亚晖, 蒋海鹰, 唐发清
Cdk3;结肠癌;免疫组织化学;原位杂交,黄大毛,王巍巍,莫莉,唐发清,冯德元,颜亚晖,蒋海鹰,通讯作者:,ExpressionofCdk3incoloncarcinogenesisanditssignificance,Da-MaoHuang,Wei-We
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黄大毛, 王巍巍, 莫莉, 唐发清, 中南大学湘雅医院检验科 湖南省长沙市 410008
冯德元, 颜亚晖, 蒋海鹰, 中南大学湘雅医学院病理学系 湖南省长沙市 410008
国家自然科学基金资助项目, No. 30572455
2006年教育部优秀人才支持计划资助项目
通讯作者: 唐发清, 410008, 湖南省长沙市湘雅路87号, 中南大学湘雅医院. tangfaqing333@hotmail.com
电话: 0731-4327168
收稿日期: 2007-07-24 修回日期: 2007-10-18
Expression of Cdk3 in colon carcinogenesis and its significance
Da-Mao Huang, Wei-Wei Wang, Li Mo, De-Yuan Feng, Ya-Hui Yan, Hai-Ying Jiang, Fa-Qing Tang
Da-Mao Huang, Wei-Wei Wang, Li Mo, Fa-Qing Tang, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
De-Yuan Feng, Ya-Hui Yan, Hai-Ying Jiang, Department of Pathology, Xiangya Medical College, Central South University, Changsha 410008, Hunan Province, China
Supported by: National Natural Science Foundation of China, No. 30572455 and Program for New Century Excellent Talents in University
Correspondence to: Professor Fa-Qing Tang, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha 410008, Hunan Province, China. tangfaqing333@hotmail.com
Received: 2007-07-24 Revised: 2007-10-18
Abstract
AIM: To investigate the expression profile of Cdk3 in colon poplyp, adenoma and its adjacent tissues and its significance in the evolution of colon cancer.
METHODS: Using immunohistochemistry and in situ hybridization, Cdk3 protein and mRNA expressions were detected in 22 cases of colon cancer, 22 cases of colonic adenoma and 24 cases of colonic polyp.
RESULTS: Immunohistochemistry and in situ hybridization showed Cdk3 protein in the cytoplasts and cytoplasms of colonic polyp, colonic adenoma and cancer tissues. Cdk3 was mainly expressed in cytoplasm. Image analysis revealed that the mean optical density of Cdk3 protein in colon cancer tissue (0.80 ± 0.36) was significantly higher than that in colon adenoma (0.48 ± 0.22) and polyp tissues (0.25 ± 0 ......
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