血管紧张素原基因T174M变异与肝硬化的相关性
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肖 凡, 魏红山, 樊文梅, 李国力
血管紧张素原;遗传多态性;肝硬化;聚合酶链式反应,肖凡,魏红山,樊文梅,李国力,通讯作者:,AssociationanalysisofT174Mvariantsoftheangiotensinogengenewithhepatocirrhosis
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肖凡, 魏红山, 樊文梅, 李国力, 北京地坛医院研究室 北京市 100011
通讯作者: 肖凡, 100011, 北京安外大街地坛公园13号地坛医院研究室. cindy2358@163.com
电话: 010-64211031-2358
收稿日期: 2007-08-21 修回日期: 2007-11-02
Association analysis of T174M variants of the angiotensinogen gene with hepatocirrhosis
Fan Xiao, Hong-Shan Wei, Wen-Mei Fan, Guo-Li Li
Fan Xiao, Hong-Shan Wei, Wen-Mei Fan, Guo-Li Li, Institute of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China
Correspondence to: Fan Xiao, Institute of Infectious Diseases, Beijing Ditan Hospital, 13 Ditan Park, Anwai Street, Beijing 100011, China. cindy2358@163.com
Received: 2007-08-21 Revised: 2007-11-02
Abstract
AIM: To detect the relationships between variants in the T174M polymorphism of the angiotensinogen gene and hepatocirrhosis.
METHODS: Genomic DNA from leukocytes was analyzed for genetic variants at the T174M polymorphism of the AGT gene by polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and automatic sequencing.
RESULTS: The distributions of MT and TT genotypes were not different between the hepatocirrhosis group (84.6%, 15.4% ) and the control group (82.8%, 17.2%) (χ2 = 0.077, P > 0.05).
CONCLUSION: T174M polymorphism in the AGT gene is not likely to be involved in hepatocirrhosis.
Key Words: Angiotensinogen; Genetic polymorphism; Hepatocirrhosis; PCR
Xiao F, Wei HS, Fan WM, Li GL. Association analysis of T174M variants of the angiotensinogen gene with hepatocirrhosis. Shijie Huaren Xiaohua Zazhi 2007; 15(35): 3752-3754
摘要
目的: 研究血管紧张素原(angiotensinogen, AGT)基因T174M分子变异与肝硬化的关系 ......
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