双环醇对小鼠日本血吸虫病肝纤维化即早基因与TGF-β1、TIMP1及胶原表达的影响
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何生松, 徐 标, 韩春荣
双环醇;日本血吸虫病;肝纤维化;即早基因;基质金属酶组织抑制因子;转化生长因子β1;逆转录聚合酶链式反应,何生松,徐标,韩春荣,何生松,通讯作者:,Effectofbicyclolontheexpressiono
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何生松, 徐标, 韩春荣, 华中科技大学同济医学院附属协和医院感染科 湖北省武汉市 430022
何生松, 主任医师, 博士导师, 主要从事病毒性肝炎、血吸虫病、酒精性肝病方面的研究.
通讯作者: 何生松, 430022, 湖北省武汉市, 华中科技大学同济医学院附属协和医院感染科. shengshe168@yahoo.com.cn
电话: 027-85726132
收稿日期: 2007-09-19 修回日期: 2007-12-04
Effect of bicyclol on the expression of hepatic immediate early genes, TGF-β1, TIMP1 and collagen in liver tissues of mice infected with Schistosoma japonicum
Sheng-Song He, Biao Xu, Chun-Rong Han
Sheng-Song He, Biao Xu, Chun-Rong Han, Department of Infectious Diseases, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Correspondence to: Sheng-Song He, Department of Infectious Diseases, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. shengshe168@yahoo.com.cn
Received: 2007-09-19 Revised: 2007-12-04
Abstract
AIM: To study the therapeutic effect of bicyclol on schistosome-infected mice with liver fibrosis and its mechanism.
METHODS: Eighty mice were divided into four groups. Mice in the low-dose, high-dose and experimental control groups were infected withSchistosoma japonicum. After eight weeks, the low-dose and high-dose groups were treated with bicyclol at 60 mg (kg· d) and 120 mg (kg· d), respectively, for 8 weeks. The experimental control group received no treatment. The fourth group was a normal control group. HE staining, RT-PCR and immunohistochemistry were used to observe the pathological changes in liver tissues of mice, the expression levels of hepatic c-fos and c-jun mRNAs, and the levels of hepatic transforming growth factor β1 (TGF-β1), tissue inhibitor of metalloproteinase 1 (TIMP1), and types I and III collagen, before and after treatment.
RESULTS: Bicyclol treatment at a high dosage significantly relieved the degree of hepatic fibrosis compared with the experimental control group ......
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