胆汁淤积诊治进展
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谢正元, 罗忠金, 张吉翔
胆汁淤积;诊断;治疗,谢正元,罗忠金,张吉翔,张吉翔,通讯作者:,Progressindiagnosisandtreatmentofcholestasis,Zheng-YuanXie,Zhong-JinLuo,Ji-XiangZhang,Supportedby:,Corr
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谢正元, 罗忠金, 张吉翔, 南昌大学第二附属医院消化内科 江西省南昌市 330006
张吉翔, 教授, 博士生导师, 主要从事消化性疾病的研究.
国家自然科学基金资助项目, No. 30360037
通讯作者: 张吉翔, 330006, 江西省南昌市, 南昌大学第二附属医院消化内科. jixiangz@163.net
电话: 0791-6292706
收稿日期: 2007-05-18 修回日期: 2007-12-04
Progress in diagnosis and treatment of cholestasis
Zheng-Yuan Xie, Zhong-Jin Luo, Ji-Xiang Zhang
Zheng-Yuan Xie, Zhong-Jin Luo, Ji-Xiang Zhang, Department of Gastroenterology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Supported by: National Natural Science Foundation of China, No. 30360037
Correspondence to: Dr. Ji-Xiang Zhang, Department of Gastroenterology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. jixiangz@163.net
Received: 2007-05-18 Revised: 2007-12-04
Abstract
Cholestasis can be considered a clinically frequent syndrome caused by complicated factors. Although investigation of cholestasis has been carried out at molecular biology level its pathogenesis can be more clearly recognized. However, the diagnosis and management of intrahepatic cholestasis has not improved. How to identify the pathophysiological and pharmacological targets of cholestatic liver disease is a challenging issue facing clinicians, pathophysiologists and pharmacologists.
Key Words: Cholestasis; Diagnosis; Treatment
Xie ZY, Luo ZJ, Zhang JX. Progress in diagnosis and treatment of cholestasis. Shijie Huaren Xiaohua Zazhi 2007; 15(35): 3669-3673
摘要
胆汁淤积(cholestasis)是临床常见的一组征候群, 产生的原因十分复杂. 尽管对胆汁淤积的研究已进入到分子学水平, 发病机制日益明确, 诊断方法及治疗药物不断更新, 但对肝内胆汁淤积的诊治仍未取得根本突破. 如何在分子水平寻找到胆汁淤积性肝病病理生理及药理作用靶点, 并进行针对性的治疗仍是临床医师、病理生理学家和药理学家共同面临的难题.
关键词: 胆汁淤积; 诊断; 治疗
谢正元, 罗忠金, 张吉翔. 胆汁淤积诊治进展. 世界华人消化杂志 2007; 15(35): 3669-3673
0 引言
B胆汁淤积(cholestasis)是指各种病因引起的胆汁生成、流动障碍, 导致胆汁不能正常进入十二指肠, 而引起的黄疸、皮肤瘙痒、心动过缓等为特征的综合征候群 ......
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