胃癌组织中P27表达与cyclin D1、cyclin E表达的相关性
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张广建, 寇有为, 王 强
胃癌;P27;周期蛋白D1;周期蛋白E,胃癌组织中P27表达与cyclinD1、cyclinE表达的相关性,张广建,寇有为,王强,通讯作者:,收稿日期:,ExpressionofP27andcyclinD1andEexpressioningastriccancer,Guang-JianZhang
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张广建, 辽宁省第三人民医院外科 辽宁省开原市 112300
寇有为, 王强, 中国医科大学盛京医院普外科 辽宁省沈阳市 110004
张广建, 硕士, 副主任医师, 主要从事胃肠外科临床工作和研究.
通讯作者: 王强, 110004, 沈阳市和平区三好街36号, 中国医科大学盛京医院普外科. wangq@cmu2h.com
电话: 024-83955060
收稿日期: 2007-05-16 修回日期: 2007-10-17
Expression of P27 and cyclin D1 and E expression in gastric cancer
Guang-Jian Zhang, You-Wei Kou, Qiang Wang
Guang-Jian Zhang, Department of Surgery, Third People's Hospital of Liaoning Province, Kaiyuan 112300, Liaoning Province, China
You-Wei Kou, Qiang Wang, Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Qiang Wang, Department of General Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Street, Heping District Shenyang 110004, Liaoning Province, China. wangq@cmu2h.com
Received: 2007-05-16 Revised: 2007-10-17
Abstract
AIM: To detect the expression of P27 and cyclin D1 and E expression in gastric cancer, and to provide a new way to diagnose and treat gastric cancer.
METHODS: Immunohistochemistry was used to examine the expression of P27, cyclin D1 and cyclin E proteins in gastric carcinoma (n = 54) and normal gastric mucosa (n = 15).
RESULTS: Positive immunohistochemistry was seen in 20 of 54 gastric cancer cases and in 11 of 15 normal gastric tissues. P27 expression differed significantly between gastric cancer and normal gastric tissue (P < 0.05), had no relation with sex, age, tumor size, invasive depth and differentiation, but had a significant relationship with TNM staging and lymph node metastasis (P < 0.05). P27 expression had a negative correlation with cyclin D1 (r = –0.332) and no relationship with cyclin E.
CONCLUSION: The difference in P27 expression in gastric cancer and normal gastric tissue is remarkable. The expression has a significant relationship with TNM staging and lymph node metastasis ......
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