中晚期胃癌术后序贯放化疗36例
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袁响林, 付 强, 胡国清, 陈 元, 张莉红, 胡广原, 于世英
中晚期胃癌;序贯放化疗;OLF方案;生存率,袁响林,付强,胡国清,陈元,张莉红,胡广原,于世英,通讯作者:,Postoperativesequencechemoradiotherapyforadvancedgastriccancer:ananalysisof36c
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袁响林, 付强, 胡国清, 陈元, 张莉红, 胡广原, 于世英, 华中科技大学同济医学院附属同济医院肿瘤中心 湖北省武汉市 430030
通讯作者: 于世英, 430030, 湖北省武汉市, 华中科技大学同济医学院附属同济医院肿瘤中心. syyu@tjh.tjmu.edu.cn
电话: 027-83662683 传真: 027-83662834
收稿日期: 2007-08-23 修回日期: 2007-11-30
Postoperative sequence chemoradiotherapy for advanced gastric cancer: an analysis of 36 cases
Xiang-Lin Yuan, Qiang Fu, Guo-Qing Hu, Yuan Chen, Li-Hong Zhang, Guang-Yuan Hu, Shi-Ying Yu
Xiang-Lin Yuan, Qiang Fu, Guo-Qing Hu, Yuan Chen, Li-Hong Zhang, Guang-Yuan Hu, Shi-Ying Yu, Oncology Center, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Shi-Ying Yu, Oncology Center, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. syyu@tjh.tjmu.edu.cn
Received: 2007-08-23 Revised: 2007-11-30
Abstract
AIM: To investigate the effect of postoperative sequence chemoradiotherapy compared with postoperative chemotherapy alone on survival of patients with advanced gastric cancer, and to evaluate the toxic effect.
METHODS: A total of 68 patients were collected from our hospital from January 2003 to December 2005. Thirty-six patients received sequence chemoradiotherapy following radical resection, and 32 patients received chemotherapy alone following radical resection. The 1- and 3-yr survival rate were evaluated, as well as the hematologic and gastrointestinal toxic effects, and liver and kidney function.
RESULTS: The 1- and 3-yr survival rate of the sequence chemoradiotherapy group was 77% and 47%, respectively, as compared with 61% and 25% in the chemotherapy only group (P = 0.041).The median survival time was 40 mo compared with 24.5 mo in the control group (P= 0.038). Grade Ⅲ–Ⅳ leukopenia occurred in 11.1% of the sequence chemoradiotherapy group compared with 6 ......
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