多希紫杉醇温敏纳米胶束对人胃癌裸鼠移植瘤的靶向治疗作用
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沈泽天, 杨 觅, 禹立霞, 钱晓萍, 刘宝瑞
胃癌;温敏纳米胶束;多希紫杉醇;靶向治疗;热疗,沈泽天,杨觅,禹立霞,钱晓萍,刘宝瑞,沈泽天,通讯作者:,Targetingtherapywithdocetaxelthermosensitivenano-micellesofhumangas
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沈泽天, 杨觅, 禹立霞, 钱晓萍, 刘宝瑞, 南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所 江苏省南京市 210008
沈泽天, 2005年南京大学医学院肿瘤学硕士生, 主要研究方向为热靶向化疗.
国家自然科学基金资助项目, No. 30670958
通讯作者: 刘宝瑞, 210008, 江苏省南京市, 南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所.
baoruiliu@hotmail.com
电话: 025-83304616-21001
收稿日期: 2007-07-31 修回日期: 2007-11-05
Targeting therapy with docetaxel thermosensitive nano-micelles of human gastric cancer xenografts in nude mice
Ze-Tian Shen, Mi Yang, Li-Xia Yu, Xiao-Ping Qian, Bao-Rui Liu
Ze-Tian Shen, Mi Yang, Li-Xia Yu, Xiao-Ping Qian, Bao-Rui Liu, Oncology Center, Affiliated Drum Tower Hospital of Nanjing University Medical School, Clinical Oncology Institute of Nanjing University, Nanjing 210008, Jiangsu Province, China
Supported by: National Natural Science Foundation of China, No. 30670958
Correspondence to: Dr. Bao-Rui Liu, Oncology Center, Affiliated Drum Tower Hospital of Nanjing University Medical School, Clinical Oncology Institute of Nanjing University, Nanjing 210008, Jiangsu Province, China. baoruiliu@hotmail.com
Received: 2007-07-31 Revised: 2007-11-05
Abstract
AIM: To study the curative effects of docetaxel thermosensitive nano-micelles on human gastric cancer xenografts in nude mice.
METHODS: Human gastric cancer cell line BGC-823 was implanted into 48 nude mice. Different drugs were injected through the caudal vein in eight groups after establishment of the experimental model. Permanent temperature of the tumor was taken in the thermotherapy group. Tumor growth was monitored once every other day. Dynamic viewing and determining the rate of tumor regression in terms of tumor weight and volume were used to evaluate therapeutic efficacy. The side effect was evaluated through surveying all the condition and the relative variation in mouse body weight.
RESULTS: Tumor growth speed in the docetaxel thermosensitive nano-micelle thermotherapy group was significantly slower than that in the other groups ......
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