GGT亚组分及基因亚型与肝癌的特异性诊断
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姚登福, 董志珍, 顾青青, 姚 敏
肝癌;γ-谷氨酰移换酶;基因;亚型,姚登福,董志珍,顾青青,姚敏,通讯作者:,Specificdiagnosisofgamma-glutamyltransferasesubfractionanditsgenotypingforhepatocellul
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姚登福, 南通大学附属医院临床分子生物学中心 江苏省南通市 226001
董志珍, 南通大学医学院诊断学教研室 江苏省南通市 226001
顾青青, 南通大学附属医院内科 江苏省南通市 226001
姚敏, 南通大学附属医院医学检验中心 江苏省南通市 226001
姚登福, 1994年在日本德岛大学获博士学位, 教授/研究员, 博士生导师, 主要从事恶性肿瘤早期诊断及其发病机制研究.
通讯作者: 姚登福, 226001, 江苏省南通市西寺路20号, 南通大学附属医院临床分子生物学中心. yaodf@ahnmc.com
电话: 0513-85052523 传真: 0513-85052254
收稿日期: 2007-05-18 修回日期: 2007-12-11
Specific diagnosis of gamma-glutamyl transferase subfraction and its genotyping for hepatocellular carcinoma
Deng-Fu Yao, Zhi-Zhen Dong, Qing-Qing Gu, Min Yao
Deng-Fu Yao, Research Center of Clinical Molecular Bio-logy, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Zhi-Zhen Dong, Department of Diagnostics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
Qing-Qing Gu, Department of Internal Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Min Yao, Department of Laboratory Science, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
Correspondence to: Dr. Deng-Fu Yao, Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Received: 2007-05-18 Revised: 2007-12-11
Abstract
Abnormal expression of total γ-glutamyl transferase (GGT, EC 2.3.2.2) activity can be found in patients with different liver diseases and extrahepatic tumors. Circulating GGT from hepatocellular carcinoma (HCC) patients can be divided into different isoforms (Ⅰ, Ⅰ’, Ⅱ, Ⅱ’, β, δ, ε, φA, ⅦB, φC, γA, γB) by using PAGE. Some of these isoforms (Ⅰ’, Ⅱ and Ⅱ’, and hepatoma-specific GGT, HS-GGT) can be detected in sera of HCC patients. Hepatic GGT gene expression may be closely related to the development of HCC. The human cDNA sequences from fetal liver, placenta and HepG2 cells (H) were investigated ......
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